Ventricular orexin-A (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in Parkinson's disease
| Autor: | Pierre Cesaro, Xavier Drouot, Jean-Pascal Lefaucheur, Laurent Margarit, Agathe Bridoux, Ala Covali-Noroc, Stéphane Moutereau, Stéphane Palfi, Jean-Paul Nguyen, Marie-Pia d'Ortho |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Pathology Parkinson's disease medicine.diagnostic_test business.industry Orexin a hypocretin 1 Rapid eye movement sleep Polysomnography Disease Positive correlation medicine.disease Sleep in non-human animals Behavioral Neuroscience Orexin-A Internal medicine Nature and Science of Sleep mental disorders Cardiology Medicine business Applied Psychology psychological phenomena and processes |
| Zdroj: | Nature and Science of Sleep. |
| ISSN: | 1179-1608 |
| Popis: | Agathe Bridoux,1,2 Stephane Moutereau,3 Ala Covali-Noroc,1 Laurent Margarit,1 Stephane Palfi,4 Jean-Paul Nguyen,5 Jean-Pascal Lefaucheur,1,2 Pierre Césaro,6 Marie-Pia d'Ortho,7 Xavier Drouot1,21Service de Physiologie, Groupe Henri Mondor, 2Faculté de Médecine, Université Paris Est Créteil, 3Service de Biochimie, Groupe Henri Mondor, 4UF Neurochirurgie Fonctionnelle, Groupe Henri Mondor, Créteil, France; 5Service de Neurochirurgie, Hôpital Nord Laënnec, Nantes, France; 6Service de Neurologie, Groupe Henri Mondor, Créteil, France; 7Service de Physiologie, Groupe Bichat – Claude Bernard, Paris, FranceObjective: Patients with Parkinson's disease frequently complain of sleep disturbances and loss of muscle atonia during rapid-eye-movement (REM) sleep is not rare. The orexin-A (hypocretin-1) hypothalamic system plays a central role in controlling REM sleep. Loss of orexin neurons results in narcolepsy-cataplexy, a condition characterized by diurnal sleepiness and REM sleep without atonia. Alterations in the orexin-A system have been also documented in Parkinson's disease, but whether these alterations have clinical consequences remains unknown.Methods: Here, we measured orexin-A levels in ventricular cerebrospinal fluid from eight patients with Parkinson's disease (four males and four females) who underwent ventriculography during deep brain-stimulation surgery and performed full-night polysomnography before surgery.Results: Our results showed a positive correlation between orexin-A levels and REM sleep without muscle atonia.Conclusion: Our results suggest that high levels of orexin-A in Parkinson's disease may be associated with loss of REM muscle atonia.Keywords: Parkinson, orexin-A, ventricular CSF, REM atonia |
| Databáze: | OpenAIRE |
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