In vitro Remineralizing Effect of Fluoride Varnishes Containing Sodium Trimetaphosphate
| Autor: | Alberto Carlos Botazzo Delbem, M. M. Manarelli, Juliano Pelim Pessan, T. M. T. Lima, F. C. N. Castilho |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Time Factors
Biopsy Varnish Inorganic chemistry Sodium trimetaphosphate urologic and male genital diseases Placebos chemistry.chemical_compound Hardness Polyphosphates Animals Fluorides Topical Dental Enamel Tooth Demineralization General Dentistry Remineralisation Anatomy Cross-Sectional Dose-Response Relationship Drug Enamel paint Chemistry Fluoride varnish Drug Synergism Hydrogen-Ion Concentration bacterial infections and mycoses Cariostatic Agents female genital diseases and pregnancy complications In vitro body regions Calcium Fluoride stomatognathic diseases Dose–response relationship Tooth Remineralization visual_art visual_art.visual_art_medium Sodium Fluoride Cattle Fluoride Nuclear chemistry |
| Zdroj: | Caries Research. 48:299-305 |
| ISSN: | 1421-976X 0008-6568 |
| DOI: | 10.1159/000356308 |
| Popis: | This study analyzed the effects of fluoride varnishes supplemented with sodium trimetaphosphate (TMP) on the remineralization of caries-like lesions in vitro. Bovine enamel discs were selected through surface hardness (SH) and caries-like lesions were induced. SH was again determined and the blocks were divided into 7 experimental groups (n = 24/group): placebo (no fluoride or TMP), 5% TMP, 2.5% NaF, 2.5% NaF/5% TMP, 5% NaF, 5% NaF/5% TMP and commercial formulation (Duraphat™, 5% NaF), following a blind protocol. Discs were treated with the varnishes and kept in a remineralizing solution for 4 h and a demineralizing solution for 2 h. Varnishes were then removed and half of the discs were used for analysis of loosely (CaF2) and firmly bound fluoride. The remaining discs were submitted to a pH-cycling regimen for 6 days. The percentage of surface hardness recovery (%SHR), cross-sectional hardness (ΔKHN) and enamel CaF2 and fluoride were determined. Data were analyzed by ANOVA and by Student-Newman-Keuls' test (p < 0.05). A dose-response relationship was observed between fluoride concentrations in the varnishes and %SHR. The 5% TMP varnish led to %SHR similar to that obtained for the placebo. When TMP was used in association with fluoride, however, significantly higher %SHR were observed in comparison with their counterparts without TMP. Moreover, ΔKHN obtained for the 5% NaF/5% TMP was significantly lower among all groups tested. Higher concentrations of CaF2 and fluoride were observed for Duraphat and 5% NaF, followed by 5% NaF/5% TMP, 2.5% NaF and 2.5% NaF/5% TMP (p < 0.05). It was concluded that the supplementation of fluoride varnishes with TMP leads to enhanced remineralizing effect of artificial caries lesions in vitro. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|