Distribution of IgG subclass anti-nuclear antibodies (ANAs) in systemic lupus erythematosus
| Autor: | Yan-Li Zeng, Jia Jia Wang, Qinghe Huang, Yun Xiao, Yan Zhang, Qinggui Chen, Xuelian Wang, Yiqiang Lin, Longcan Jiang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male musculoskeletal diseases 0301 basic medicine Adolescent Anti-nuclear antibody Enzyme-Linked Immunosorbent Assay Subclass Young Adult 03 medical and health sciences 0302 clinical medicine Rheumatology Antibody Specificity immune system diseases Humans Lupus Erythematosus Systemic Distribution (pharmacology) Medicine In patient Child skin and connective tissue diseases Aged 030203 arthritis & rheumatology biology business.industry Igg subclasses Middle Aged stomatognathic diseases 030104 developmental biology Antibodies Antinuclear Case-Control Studies Immunoglobulin G Immunology Linear Models biology.protein Female Antibody business |
| Zdroj: | Lupus. 30:901-912 |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1177/0961203321995242 |
| Popis: | Objectives Our study purpose was to detect the distribution of anti-nuclear antibody (ANA) IgG subclasses in patients with systemic lupus erythematosus (SLE) and to evaluate their influence on the inflammatory process in SLE. Methods We determined the serum levels of ANA IgG subclasses from 70 SLE patients, 25 patients with other autoimmune diseases (OAD), and 25 healthy controls using ELISA. The serum level of total ANA IgG and the avidity of ANA IgG, dsDNA IgG, and dsDNA IgG subclasses were analysed by ELISA. Results The results indicated that levels of four ANA IgG subclasses (IgG1, IgG2, IgG3 and IgG4) and total IgG were significantly higher in SLE patients than in OAD patients and healthy controls ( p Conclusions First, we demonstrated that the ANA IgG subclasses were diagnostic tools in SLE patients. Furthermore, HA IgG ANAs might affect the distribution of ANA IgG3 and IgG4. Moreover, ANA IgG3 might play a particular role in the activity of SLE disease and therapy. Therefore, an altered ANA IgG subclass distribution might be a risk factor influencing the inflammatory process in SLE. |
| Databáze: | OpenAIRE |
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