Chronic Infusion of Astaxanthin Into Hypothalamic Paraventricular Nucleus Modulates Cytokines and Attenuates the Renin–Angiotensin System in Spontaneously Hypertensive Rats
| Autor: | Qiu-Yue Yi, Yu-Ming Kang, Ying Li, Kai-Li Liu, Hua Tian, Hong-Li Gao, Jin-Jun Liu, Yi-Yi Zuo, Guo-Qing Zhu, Dong-Dong Zhang, Li-Yan Fu, Xiao-Min Wang, Kai B Kang, Xiao-Lian Shi, Jia-Yue Yu, Jie Qi, Xiao-Jing Yu, Yan-Mei Chen |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Time Factors Anti-Inflammatory Agents Inflammation Xanthophylls 030204 cardiovascular system & hematology medicine.disease_cause Rats Inbred WKY Proinflammatory cytokine Renin-Angiotensin System Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Astaxanthin Rats Inbred SHR Internal medicine Renin–angiotensin system medicine Animals Arterial Pressure Infusions Parenteral Receptor Antihypertensive Agents Pharmacology chemistry.chemical_classification Reactive oxygen species Chemistry Disease Models Animal 030104 developmental biology Endocrinology Hypertension Cytokines Inflammation Mediators medicine.symptom Cardiology and Cardiovascular Medicine hormones hormone substitutes and hormone antagonists Oxidative stress Paraventricular Hypothalamic Nucleus |
| Zdroj: | Journal of Cardiovascular Pharmacology. 77:170-181 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/fjc.0000000000000953 |
| Popis: | Oxidative stress, the renin-angiotensin system (RAS), and inflammation are some of the mechanisms involved in the pathogenesis of hypertension. The aim of this study is to examine the protective effect of the chronic administration of astaxanthin, which is extracted from the shell of crabs and shrimps, into hypothalamic paraventricular nucleus (PVN) in spontaneously hypertensive rats. Animals were randomly assigned to 2 groups and treated with bilateral PVN infusion of astaxanthin or vehicle (artificial cerebrospinal fluid) through osmotic minipumps (Alzet Osmotic Pumps, Model 2004, 0.25 μL/h) for 4 weeks. Spontaneously hypertensive rats had higher mean arterial pressure and plasma level of norepinephrine and proinflammatory cytokine; higher PVN levels of reactive oxygen species, NOX2, NOX4, IL-1β, IL-6, ACE, and AT1-R; and lower PVN levels of IL-10 and Cu/Zn SOD, Mn SOD, ACE2, and Mas receptors than Wistar-Kyoto rats. Our data showed that chronic administration of astaxanthin into PVN attenuated the overexpression of reactive oxygen species, NOX2, NOX4, inflammatory cytokines, and components of RAS within the PVN and suppressed hypertension. The present results revealed that astaxanthin played a role in the brain. Our findings demonstrated that astaxanthin had protective effect on hypertension by improving the balance between inflammatory cytokines and components of RAS. |
| Databáze: | OpenAIRE |
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