Octreotide Treatment Does Not Improve Impaired Glucose Uptake in Cirrhosis
| Autor: | E. Shmueli, H. Ørskov, C. O. Record, K. G. M. M. Alberti |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Blood Glucose Liver Cirrhosis Male medicine.medical_specialty Cirrhosis Endocrinology Diabetes and Metabolism medicine.medical_treatment Glucose uptake Clinical Biochemistry Octreotide Fatty Acids Nonesterified Biochemistry Endocrinology Insulin resistance Internal medicine medicine Humans Insulin Pancreatic hormone Glucose tolerance test C-Peptide medicine.diagnostic_test business.industry Biochemistry (medical) Fasting General Medicine Middle Aged medicine.disease Somatostatin Glucose Clamp Technique Insulin Resistance business medicine.drug |
| Zdroj: | Hormone and Metabolic Research. 25:317-320 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-2007-1002108 |
| Popis: | Forearm glucose uptake during a hyperglycaemic (10 mmol/l) glucose clamp was diminished to 33% of the normal value (p = 0.012) in six cirrhotic patients compared with matched control subjects. Fasting insulin concentrations were significantly elevated in the cirrhotic patients confirming insulin resistance which may have been induced by chronic hyperinsulinaemia. The cirrhotic patients received one week of treatment with 50 micrograms octreotide subcutaneously three times daily which reduced pre-dose fasting insulin levels from 26.2 +/- 7.9 to 18.1 +/- 6.2 mU/l p < 0.005, and post dose levels to 7.0 +/- 3.5 mU/l p < 0.005. However when the glucose clamp was repeated 20 hours after the last dose of octreotide no change was detected in clamp glucose requirements, forearm glucose uptake, or stimulated insulin secretion. It was concluded that one week of lowering insulin levels does not reverse the insulin resistance of cirrhosis. |
| Databáze: | OpenAIRE |
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