Synthesis, antiplatelet and in silico evaluations of novel N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides
| Autor: | Anna C. Cunha, Eduardo C.L. Carlos, Alessandro K. Jordão, Maria Cecília B. V. de Souza, Maria C.B. Almeida, Emerson Silva Lima, C. R. Rodrigues, Vitor F. Ferreira, Reinaldo B Geraldo, Helena Carla Castro |
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| Rok vydání: | 2009 |
| Předmět: |
chemistry.chemical_classification
1 2 3-Triazole Platelet Aggregation Molecular model Chemistry Stereochemistry In silico Organic Chemistry Clinical Biochemistry Pharmaceutical Science Hydrazone Human platelet Triazoles Biochemistry Chemical synthesis In vitro Structure-Activity Relationship chemistry.chemical_compound Hydrazines Drug Discovery Humans Molecular Medicine Arachidonic acid Molecular Biology Platelet Aggregation Inhibitors |
| Zdroj: | Bioorganic & Medicinal Chemistry. 17:3713-3719 |
| ISSN: | 0968-0896 |
| Popis: | This paper describes the synthesis, antiplatelet and theoretical evaluations of 10 N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides (2a-j). These compounds were synthesized, characterized and screened for their in vitro antiplatelet profile against human platelet aggregation using arachidonic acid, adrenaline and ADP as agonists. Among NAH derivatives 2a-j, the compounds 2a, 2c, 2e, 2g and 2h were the most promising molecules with significant antiplatelet activity. |
| Databáze: | OpenAIRE |
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