Synthesis, antiplatelet and in silico evaluations of novel N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides

Autor: Anna C. Cunha, Eduardo C.L. Carlos, Alessandro K. Jordão, Maria Cecília B. V. de Souza, Maria C.B. Almeida, Emerson Silva Lima, C. R. Rodrigues, Vitor F. Ferreira, Reinaldo B Geraldo, Helena Carla Castro
Rok vydání: 2009
Předmět:
Zdroj: Bioorganic & Medicinal Chemistry. 17:3713-3719
ISSN: 0968-0896
Popis: This paper describes the synthesis, antiplatelet and theoretical evaluations of 10 N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides (2a-j). These compounds were synthesized, characterized and screened for their in vitro antiplatelet profile against human platelet aggregation using arachidonic acid, adrenaline and ADP as agonists. Among NAH derivatives 2a-j, the compounds 2a, 2c, 2e, 2g and 2h were the most promising molecules with significant antiplatelet activity.
Databáze: OpenAIRE