Effect of somatostatin on blood sugar, plasma growth hormone, and glucagon levels in diabetic children
| Autor: | Giuseppe Chiumello, C. Garlaschi, B. di Natale, M. J. Del Guercio, L. Gargantini |
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| Rok vydání: | 1976 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism Blood sugar Glucagon Plasma growth hormone Bolus (medicine) Internal medicine Diabetes mellitus medicine Internal Medicine Humans Child business.industry Glucagon secretion Plasma gh medicine.disease Endocrinology Somatostatin Diabetes Mellitus Type 1 Child Preschool Growth Hormone Female business |
| Zdroj: | Diabetes. 25:550-553 |
| ISSN: | 0012-1797 |
| Popis: | In nine children with clinically overt insulin-dependent diabetes mellitus the authors injected cyclic somatostatin (3 mug./kg. bolus, followed by infusion of 13 mug./kg. in 60 minutes) and measured blood glucose, plasma growth hormone, and glucagon concentrations throughout the infusion. The rapid administration produced no significant changes of these parameters. With the prolonged infusion there was a significant reduction of blood glucose from a mean of 148 ± 19.7 to a mean of 88.5 ± 18.1 mg./100 ml. (P < 0.005) and of plasma glucagon from a basal mean of 33.3 ± 2.4 to a minimum mean of 22.1 ± 1.7 pg./ml. (P < 0.01). There was a statistically significant correlation between the two parameters (0.01 < P < 0.05). Plasma GH values also diminished during the infusion, but the reduction was not statistically significant. These results show that somatostatin lowers blood glucose concentrations as a secondary effect of inhibition of glucagon secretion. Somatostatin is not suitable for therapy in diabetes. We speculate that a similar substance with a more prolonged and specific action on glucagon might prove of practical value in the treatment of diabetes mellitus. |
| Databáze: | OpenAIRE |
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