Predictive effects of body mass index on immune reconstitution among HIV-infected HAART users in China

Autor:	Haibo Ding, Xiaolin Li, Hong Shang, Wenqing Geng, Zining Zhang, Yongjun Jiang, Jing Liu, Junjie Xu
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Adult CD4-Positive T-Lymphocytes Male 0301 basic medicine medicine.medical_specialty China 030106 microbiology HIV Infections Overweight Gastroenterology lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Antiretroviral Therapy Highly Active Internal medicine medicine Humans lcsh:RC109-216 Longitudinal Studies 030212 general & internal medicine Body mass index Proportional Hazards Models business.industry Proportional hazards model Hazard ratio Age Factors nutritional and metabolic diseases HIV Middle Aged Viral Load Immune reconstitution medicine.disease Obesity Confidence interval CD4 Lymphocyte Count Antiretroviral therapy Infectious Diseases Linear Models RNA Viral Female medicine.symptom Underweight business Viral load Research Article
Zdroj:	BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-9 (2019) BMC Infectious Diseases
ISSN:	1471-2334
Popis:	Background Body mass index (BMI) may contribute somewhat to drug metabolism, and thus affecting the efficacy of highly active antiretroviral therapy (HAART). This study aimed to determine the frequencies of underweight, normal and overweight/obesity at pre-HAART in a large cohort of HIV-infected Chinese patients, and investigate the prospective effects of BMI on immune reconstitution after HAART initiation. Methods A longitudinal cohort study was performed to analyze the effects of BMI on immune reconstitution in HIV-infected patients treated with HAART. Multiple linear regression was used to evaluate the relationship between baseline BMI and increased CD4+ T lymphocyte levels at 12 and 30 months after initiating HAART. In addition, Cox proportional hazard model was used to assess the relationship between BMI and time to achieve immunologic reconstitution (CD4+ T lymphocytes>500cells/μL) during the follow-up period. Results Among the 1612 enrolled patients, 283 (17.6%) were overweight/obese (BMI ≥ 25 kg/m2), 173 (10.7%) were underweight (BMI
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d6d3c04800cd86261aaf8140cacd95 http://link.springer.com/article/10.1186/s12879-019-3991-6 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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