Role of caspases in the regulation of apoptotic pancreatic islet beta-cells death
| Autor: | Francesco Dotta, Umberto Di Mario, Hongxiang Hui, Riccardo Perfetti |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Physiology
Clinical Biochemistry Apoptosis Models Biological Islets of Langerhans Enzyme activator Diabetes mellitus Diabetes Mellitus medicine Animals Humans Pancreas Caspase geography geography.geographical_feature_category biology Intrinsic apoptosis Cell Biology Islet medicine.disease Cell biology Enzyme Activation Transplantation Caspases biology.protein Homeostasis |
| Zdroj: | Journal of Cellular Physiology. 200:177-200 |
| ISSN: | 1097-4652 0021-9541 |
| Popis: | The homeostatic control of beta-cell mass in normal and pathological conditions is based on the balance of proliferation, differentiation, and death of the insulin-secreting cells. A considerable body of evidence, accumulated during the last decade, has emphasized the significance of the disregulation of the mechanisms regulating the apoptosis of beta-cells in the sequence of events that lead to the development of diabetes. The identification of agents capable of interfering with this process needs to be based on a better understanding of the beta-cell specific pathways that are activated during apoptosis. The aim of this article is fivefold: (1) a review of the evidence for beta-cell apoptosis in Type I diabetes, Type II diabetes, and islet transplantation, (2) to review the common stimuli and their mechanisms in pancreatic beta-cell apoptosis, (3) to review the role of caspases and their activation pathway in beta-cell apoptosis, (4) to review the caspase cascade and morphological cellular changes in apoptotic beta-cells, and (5) to highlight the putative strategies for preventing pancreatic beta-cells from apoptosis. |
| Databáze: | OpenAIRE |
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