Doxofylline exerts a prophylactic effect against bronchoconstriction and pleurisy induced by PAF
| Autor: | J.S. Franzone, R. Cirillo, P. Biffignandi |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.drug_class Guinea Pigs Bronchi In Vitro Techniques Pharmacology Binding Competitive Injections Thromboxane A2 chemistry.chemical_compound Theophylline Bronchodilator medicine Animals Anesthesia Platelet Activating Factor Lung Pleurisy Doxofylline Leukotriene Platelet-activating factor business.industry Airway Resistance respiratory system Bronchodilator Agents medicine.anatomical_structure chemistry Mechanism of action Injections Intravenous Immunology Female lipids (amino acids peptides and proteins) Bronchoconstriction medicine.symptom business Muscle Contraction medicine.drug |
| Zdroj: | European Journal of Pharmacology. 165:269-277 |
| ISSN: | 0014-2999 |
| Popis: | The effect of doxofylline, a new xanthine drug with a low incidence of side-effects in the central nervous, renal and gastroenteric system, on the actions of PAF-acether on bronchopulmonary functions was studied. Doxofylline inhibited: (1) PAF-induced bronchoconstriction in vitro, and the concomitant generation of TXA2-like activity in perfused guinea-pig lungs; (2) PAF-induced bronchoconstriction in vivo and the concomitant release of TXA2-like activity into the circulation; (3) PAF-acether-induced pleurisy and the liberation of type C4 leukotriene into the rat pleural cavity. The results suggest that doxofylline, like theophylline, is able to counteract the bronchoconstriction induced by PAF-acether and, in addition, displays anti-inflammatory properties. These pharmacological data support the notion that doxofylline exerts a prophylactic effect against the respiratory damage induced by mediators, such as PAF-acether, of lung bronchial hyperreactivity; its mechanism of action is unusual, it has slight antagonistic activity at A1- and A2-adenosine receptors. |
| Databáze: | OpenAIRE |
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