The brain as an insulin-sensitive metabolic organ
| Autor: | Joshua L. Milstein, Heather A. Ferris |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Blood Glucose medicine.medical_treatment Central nervous system 030209 endocrinology & metabolism Review 03 medical and health sciences 0302 clinical medicine Insulin resistance Alzheimer Disease medicine Animals Humans Insulin Cognitive decline Molecular Biology Internal medicine Administration Intranasal biology business.industry Neurodegeneration Brain Intranasal insulin Cell Biology Alzheimer's disease medicine.disease RC31-1245 Receptor Insulin Insulin receptor Disease Models Animal 030104 developmental biology medicine.anatomical_structure Blood-Brain Barrier Mitochondrial metabolism biology.protein Blood sugar regulation business Neuroscience Homeostasis |
| Zdroj: | Molecular Metabolism, Vol 52, Iss, Pp 101234-(2021) Molecular Metabolism |
| ISSN: | 2212-8778 |
| Popis: | Background The brain was once thought of as an insulin-insensitive organ. We now know that the insulin receptor is present throughout the brain and serves important functions in whole-body metabolism and brain function. Brain insulin signaling is involved not only in brain homeostatic processes but also neuropathological processes such as cognitive decline and Alzheimer's disease. Scope of review In this review, we provide an overview of insulin signaling within the brain and the metabolic impact of brain insulin resistance and discuss Alzheimer's disease, one of the neurologic diseases most closely associated with brain insulin resistance. Major conclusions While brain insulin signaling plays only a small role in central nervous system glucose regulation, it has a significant impact on the brain's metabolic health. Normal insulin signaling is important for mitochondrial functioning and normal food intake. Brain insulin resistance contributes to obesity and may also play an important role in neurodegeneration. Highlights • Insulin is an important regulator of brain metabolism. • Brain insulin signaling helps regulate whole body metabolism. • Brain insulin signaling may play an important role in the pathogenesis of Alzheimer's disease. |
| Databáze: | OpenAIRE |
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