Long-term follow-up of 13C-urea breath test results after Helicobacter pylori eradication: frequency and significance of borderline delta13CO2 values
| Autor: | David Olivares, José María Pajares, Javier P. Gisbert, I. Jimenez |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Diagnostic methods Long term follow up Spirillaceae Urea breath test Sensitivity and Specificity Gastroenterology Helicobacter Infections 13C urea breath test chemistry.chemical_compound Predictive Value of Tests Recurrence Internal medicine medicine Humans Urea Pharmacology (medical) Prospective Studies Breath test Carbon Isotopes Helicobacter pylori Hepatology biology medicine.diagnostic_test business.industry Middle Aged biology.organism_classification Long-Term Care Surgery Breath Tests chemistry Female business Follow-Up Studies |
| Zdroj: | Alimentary Pharmacology and Therapeutics. 23:275-280 |
| ISSN: | 1365-2036 0269-2813 |
| Popis: | The precise choice of cut-off point for the 13C-urea breath test to define whether it is positive or negative represents a controversial issue.To quantify the 13C-urea breath test result for several years following Helicobacter pylori eradication, and to evaluate the frequency and the significance of borderline delta13CO2 values.Two-hundred H. pylori eradicated patients confirmed by 13C-urea breath test (100 mg of urea, citric acid), and having had repeated this test yearly up to 5 years, were studied. Delta13CO2 values between 2 and 5/1000 were considered as borderline results.Eight H. pylori recurrences were observed during 406 patient-years of follow-up (1.97% yearly). In two of eight reinfected patients, the reinfection was preceded by a negative delta13CO2 value2/1000. Borderline delta13CO2 values were detected in 4% of the 606 urea breath tests performed, and in 25% when only patients in whom H. pylori recurrence was detected in subsequent urea breath tests were included (P0.05). The negative-predictive value of a post-treatment delta13CO22/1000 for the diagnosis of H. pylori recurrence was 99%.Positive and negative urea breath test results tend to cluster outside the range between 2/1000 and 5/1000. Nevertheless, a borderline urea breath test delta value (e.g. very close to the selected cut-off point) should be interpreted cautiously, and the result should probably be confirmed either by repeating the urea breath test or by other diagnostic methods. On the contrary, a delta13CO2 value2/1000 very confidently confirms H. pylori eradication. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |