Chemical Screening Method for the Rapid Identification of Microbial Sources of Marine Invertebrate-Associated Metabolites
| Autor: | Brad Haltli, Jo Withers, Fabrice Berrué, Sydnor T. Withers, Russell G. Kerr |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
chemical screening
gorgonian coral Microorganism Pharmaceutical Science Marine Biology 01 natural sciences Article Mass Spectrometry coral-associated bacteria UPLC/MS 03 medical and health sciences Drug Discovery Animals 14. Life underwater lcsh:QH301-705.5 Pharmacology Toxicology and Pharmaceutics (miscellaneous) Chromatography High Pressure Liquid Invertebrate Marine biology Invertebrate host Biological Products 0303 health sciences Bacteria biology 010405 organic chemistry 030306 microbiology Ecology Marine invertebrates Anthozoa biology.organism_classification Invertebrates 0104 chemical sciences Chemical screening Rapid identification lcsh:Biology (General) |
| Zdroj: | Marine Drugs; Volume 9; Issue 3; Pages: 369-381 Marine Drugs, Vol 9, Iss 3, Pp 369-381 (2011) Marine Drugs |
| ISSN: | 1660-3397 |
| DOI: | 10.3390/md9030369 |
| Popis: | Marine invertebrates have proven to be a rich source of secondary metabolites. The growing recognition that marine microorganisms associated with invertebrate hosts are involved in the biosynthesis of secondary metabolites offers new alternatives for the discovery and development of marine natural products. However, the discovery of microorganisms producing secondary metabolites previously attributed to an invertebrate host poses a significant challenge. This study describes an efficient chemical screening method utilizing a 96-well plate-based bacterial cultivation strategy to identify and isolate microbial producers of marine invertebrate-associated metabolites. |
| Databáze: | OpenAIRE |
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