Differential Modulation of Clock Speed by the Administration of Intermittent Versus Continuous Cocaine
| Autor: | Matthew S. Matell, George R King, Warren H. Meck |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Differential modulation medicine.medical_specialty business.industry Clock rate Time perception Rats Developmental psychology Rats Sprague-Dawley Sprague dawley Behavioral Neuroscience medicine.anatomical_structure Endocrinology Cocaine Osmotic minipump Biological Clocks Drug tolerance Internal medicine Reaction Time Animals Medicine Temporal perception business Sensitization |
| Zdroj: | Behavioral Neuroscience. 118:150-156 |
| ISSN: | 1939-0084 0735-7044 |
| DOI: | 10.1037/0735-7044.118.1.150 |
| Popis: | The roles that psychostimulant sensitization and tolerance play in temporal perception in the seconds-to-minutes range were assessed in rats. Cocaine (20 mg/kg/day) was administered for 2 weeks either intermittently via daily injections (induces sensitization) or continuously via an osmotic minipump (induces tolerance). Interval timing was evaluated throughout administration and withdrawal. Injections of cocaine caused immediate, proportional, leftward shifts in peak times, indicating an increase in the speed of an internal clock. These shifts grew progressively larger with repeated administration, indicating that stimulant-induced increases in clock speed can be sensitized. Continuous cocaine administration produced no reliable effects. These results suggest that the mechanisms of sensitization may play a considerable role in drug-induced alterations of the perception of time. |
| Databáze: | OpenAIRE |
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