Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation
| Autor: | Erwin R. Schmidt, Swenja Kröller-Schön, Philipp S. Wild, Axel Heimann, Katrin Frauenknecht, Katie Frenis, Sanela Kalinovic, Ksenija Vujacic-Mirski, Konstantina Filippou, Sebastian Steven, Matthias Klein, Markus Dudek, Markus Bosmann, Miroslava Kvandova, Hanke Mollnau, Omar Hahad, Axel Methner, Antonio Pinto, Tobias Bopp, Matthias Oelze, Thomas Münzel, Steffen Rapp, Frank P. Schmidt, Andreas Daiber |
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| Přispěvatelé: | University of Zurich, Münzel, Thomas |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endothelium Aircraft 10208 Institute of Neuropathology Inflammation 610 Medicine & health 030204 cardiovascular system & hematology Systemic inflammation medicine.disease_cause 2705 Cardiology and Cardiovascular Medicine 03 medical and health sciences 0302 clinical medicine Basic Science Vascular Biology Internal medicine eNOS uncoupling medicine Humans Endothelial dysfunction business.industry Environmental stressor Cerebral redox balance medicine.disease Sleep deprivation Noise Oxidative Stress 030104 developmental biology medicine.anatomical_structure Endocrinology NADPH oxidase-derived oxidative stress 570 Life sciences biology medicine.symptom business Cardiology and Cardiovascular Medicine Oxidative stress Noise exposure |
| Zdroj: | European Heart Journal |
| DOI: | 10.5167/uzh-160646 |
| Popis: | Aims Aircraft noise causes endothelial dysfunction, oxidative stress, and inflammation. Transportation noise increases the incidence of coronary artery disease, hypertension, and stroke. The underlying mechanisms are not well understood. Herein, we investigated effects of phagocyte-type NADPH oxidase (Nox2) knockout and different noise protocols (around-the-clock, sleep/awake phase noise) on vascular and cerebral complications in mice. Methods and results C57BL/6j and Nox2 −/− (gp91phox −/−) mice were exposed to aircraft noise (maximum sound level of 85 dB(A), average sound pressure level of 72 dB(A)) around-the-clock or during sleep/awake phases for 1, 2, and 4 days. Adverse effects of around-the-clock noise on the vasculature and brain were mostly prevented by Nox2 deficiency. Around-the-clock aircraft noise of the mice caused the most pronounced vascular effects and dysregulation of Foxo3/circadian clock as revealed by next generation sequencing (NGS), suggesting impaired sleep quality in exposed mice. Accordingly, sleep but not awake phase noise caused increased blood pressure, endothelial dysfunction, increased markers of vascular/systemic oxidative stress, and inflammation. Noise also caused cerebral oxidative stress and inflammation, endothelial and neuronal nitric oxide synthase (e/nNOS) uncoupling, nNOS mRNA and protein down-regulation, and Nox2 activation. NGS revealed similarities in adverse gene regulation between around-the-clock and sleep phase noise. In patients with established coronary artery disease, night-time aircraft noise increased oxidative stress, and inflammation biomarkers in serum. Conclusion Aircraft noise increases vascular and cerebral oxidative stress via Nox2. Sleep deprivation and/or fragmentation caused by noise triggers vascular dysfunction. Thus, preventive measures that reduce night-time aircraft noise are warranted. |
| Databáze: | OpenAIRE |
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