The Role of Postoperative Radiotherapy in Intracranial Solitary Fibrous Tumor/Hemangiopericytoma: A Multi-institutional Retrospective Study (KROG 18-11)
| Autor: | Su Jeong Kang, Jong Hee Chang, Il Han Kim, In Ah Kim, Chang Ok Suh, Chan Woo Wee, Joo Ho Lee, Chul-Kee Park, Jung Ho Im, Do Hoon Lim, Sung Hwan Kim, Hong In Yoon, Jinhee Kim, Seung Hyuck Jeon, Sung Hye Park |
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| Rok vydání: | 2022 |
| Předmět: |
Adult
Male 0301 basic medicine Cancer Research medicine.medical_specialty Solitary fibrous tumor Multivariate analysis Adolescent medicine.medical_treatment Urology Postoperative radiotherapy Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Port (medical) medicine Humans Postoperative Child Margin Aged Retrospective Studies Postoperative Care Hemangiopericytoma Radiotherapy Brain Neoplasms business.industry Retrospective cohort study Middle Aged medicine.disease Intracranial Progression-Free Survival CNS cancer Radiation therapy 030104 developmental biology Oncology Multicenter study Solitary Fibrous Tumors 030220 oncology & carcinogenesis Original Article Female business |
| Zdroj: | Cancer Research and Treatment : Official Journal of Korean Cancer Association |
| ISSN: | 2005-9256 1598-2998 |
| Popis: | Purpose This study aimed to evaluate the role of postoperative radiotherapy (PORT) in intracranial solitary fibrous tumor/hemangiopericytoma (SFT/HPC).Materials and Methods A total of 133 patients with histologically confirmed HPC were included from eight institutions. Gross total resection (GTR) and subtotal resection (STR) were performed in 86 and 47 patients, respectively. PORT was performed in 85 patients (64%). The prognostic effects of sex, age, performance, World Health Organization (WHO) grade, location, size, Ki-67, surgical extent, and PORT on local control (LC), distant metastasis-free survival (DMFS), progression-free survival (PFS), and overall survival (OS) were estimated by univariate and multivariate analyses.Results The 10-year PFS, and OS rates were 45%, and 71%, respectively. The multivariate analysis suggested that PORT significantly improved LC (p < 0.001) and PFS (p < 0.001). The PFS benefit of PORT was maintained in the subgroup of GTR (p=0.001), WHO grade II (p=0.001), or STR (p < 0.001). In the favorable subgroup of GTR and WHO grade II, PORT was also significantly related to better PFS (p=0.028). WHO grade III was significantly associated with poor DMFS (p=0.029). In the PORT subgroup, the 0-0.5 cm margin of the target volume showed an inferior LC to a large margin with 1.0-2.0 cm (p=0.021). Time-dependent Cox proportion analysis showed that distant failures were significantly associated with poor OS (p=0.003).Conclusion This multicenter study supports the role of PORT in disease control of intracranial SFT/HPC, irrespective of the surgical extent and grade. For LC, PORT should enclose the tumor bed with sufficient margin. |
| Databáze: | OpenAIRE |
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