A novel vesicular carrier, transethosome, for enhanced skin delivery of voriconazole: Characterization and in vitro/in vivo evaluation
| Autor: | Suk-Jae Chung, Dae-Duk Kim, Prabagar Balakrishnan, Saeho Chong, Chang-Koo Shim, Chung Kil Song |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Skin Absorption Phospholipid Polyethylene glycol Administration Cutaneous Mice chemistry.chemical_compound Drug Delivery Systems Colloid and Surface Chemistry In vivo hemic and lymphatic diseases Zeta potential Animals Physical and Theoretical Chemistry Lipid bilayer Skin Drug Carriers Mice Hairless Liposome Chromatography Vesicle Surfaces and Interfaces General Medicine Triazoles Permeation Elasticity Pyrimidines chemistry Liposomes Voriconazole Biotechnology |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 92:299-304 |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/j.colsurfb.2011.12.004 |
| Popis: | This study describes a novel carrier, transethosome, for enhanced skin delivery of voriconazole. Transethosomes (TELs) are composed of phospholipid, ethanol, water and edge activator (surfactants) or permeation enhancer (oleic acid). Characterization of the TELs was based on results from recovery, particle size, transmission electron microscopy (TEM), zeta potential and elasticity studies. In addition, skin permeation profile was obtained using static vertical diffusion Franz cells and hairless mouse skin treated with TELs containing 0.3% (w/w) voriconazole, and compared with those of ethosomes (ELs), deformable liposomes (DLs), conventional liposomes (CLs) and control (polyethylene glycol, PG) solutions. The recovery of the studied vesicles was above 90% in all vesicles, as all of them contained ethanol (7-30%). There was no significant difference in the particles size of all vesicles. The TEM study revealed that the TELs were in irregular spherical shape, implying higher fluidity due to perturbed lipid bilayer compared to that of other vesicles which were of spherical shape. The zeta potential of vesicles containing sodium taurocholate or oleic acid showed higher negative value compared to other vesicles. The elasticities of ELs and TELs were much higher than that of CLs and DLs. Moreover, TELs dramatically enhanced the skin permeation of voriconazole compared to the control and other vesicles (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect