Understanding and countering opioid‐induced respiratory depression
| Autor: | Jordan T. Bateman, Erica S. Levitt, Sandy E. Saunders |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pharmacology medicine.medical_specialty business.industry Addiction media_common.quotation_subject Opioid overdose medicine.disease Article Respiratory pharmacology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Opioid Naloxone medicine Breathing Respiratory system Intensive care medicine business 030217 neurology & neurosurgery Depression (differential diagnoses) medicine.drug media_common |
| Zdroj: | Br J Pharmacol |
| ISSN: | 1476-5381 0007-1188 |
| DOI: | 10.1111/bph.15580 |
| Popis: | Respiratory depression is the proximal cause of death in opioid overdose, yet the mechanisms underlying this potentially fatal outcome are not well understood. The goal of this review is to provide a comprehensive understanding of the pharmacological mechanisms of opioid-induced respiratory depression, which could lead to improved therapeutic options to counter opioid overdose, as well as other detrimental effects of opioids on breathing. The development of tolerance in the respiratory system is also discussed, as are differences in the degree of respiratory depression caused by various opioid agonists. Finally, potential future therapeutic agents aimed at reversing or avoiding opioid-induced respiratory depression through non-opioid receptor targets are in development and could provide certain advantages over naloxone. By providing an overview of mechanisms and effects of opioids in the respiratory network, this review will benefit future research on countering opioid-induced respiratory depression. |
| Databáze: | OpenAIRE |
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