Cyclooxygenase-2 expression correlates with diminished survival in invasive breast cancer treated with mastectomy and radiotherapy
| Autor: | R. Jeffrey Lee, Jennifer Fischbach, John K O'Connor, James M. Avent, David K. Gaffney |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty medicine.medical_treatment Statistics as Topic Breast Neoplasms Breast cancer Internal medicine medicine Distribution (pharmacology) Humans Radiology Nuclear Medicine and imaging In patient Stage (cooking) Lymph node Mastectomy Radiation biology business.industry Membrane Proteins medicine.disease Prognosis Combined Modality Therapy Neoplasm Proteins Radiation therapy Isoenzymes Survival Rate medicine.anatomical_structure Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases biology.protein Female Cyclooxygenase business |
| Zdroj: | International journal of radiation oncology, biology, physics. 58(4) |
| ISSN: | 0360-3016 |
| Popis: | To evaluate the relationship between cyclooxygenase-2 (COX-2) expression and pathologic features and outcome in invasive breast cancer.Formalin-fixed, paraffin-embedded tumor specimens from 23 women with invasive breast cancer were stained for COX-2 expression. All women underwent mastectomy and locoregional radiotherapy. The distribution (percentage of positive staining cells) and intensity of COX-2 expression within the tumor cells were compared with clinical factors, including stage, grade, lymph node involvement, and outcome.For invasive breast cancer, the distribution and intensity of COX-2 tumor expression correlated significantly with diminished overall survival. The 5-year overall survival rate was 100% for patients with75% of breast cancer cells expressing COX-2 compared with 49% for patients withor =75% (p = 0.044). The 5-year overall survival rate was 100% for patients with COX-2 intensity80 compared with 60% for patients with COX-2 intensityor =80 (p = 0.018). The percentage and intensity of COX-2 expression also correlated significantly with disease-free survival. The percentage of cells expressing COX-2 was significantly greater in women40 years old than in womenor =40 years old (81% vs. 59%, respectively, p = 0.04).Both the distribution and the intensity of COX-2 expression correlated significantly with disease-free and overall survival in patients with invasive breast cancer. Younger patients with invasive breast cancer may have a greater percentage of COX-2 expression in their tumors. |
| Databáze: | OpenAIRE |
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