The Gene for Human Glutaredoxin (GLRX) Is Localized to Human Chromosome 5q14
| Autor: | Bajalica S, Holmgren A, Padilla Ca, Lagercrantz J |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
DNA
Complementary Hybrid Cells Biology Mice Gene mapping Cricetinae Glutaredoxin Complementary DNA Genetics medicine Animals Humans Genomic library Gene Glutaredoxins In Situ Hybridization Fluorescence medicine.diagnostic_test cDNA library Chromosome Mapping Proteins DNA Molecular biology Genes Chromosomal region Chromosomes Human Pair 5 Oxidoreductases Fluorescence in situ hybridization |
| Zdroj: | Genomics. 32:455-457 |
| ISSN: | 0888-7543 |
| DOI: | 10.1006/geno.1996.0141 |
| Popis: | Glutaredoxin is a small protein (12 kDa) catalyzing glutathione-dependent disulfide oxidoreduction reactions in a coupled system with NADPH, GSH, and glutathione reductase. A cDNA encoding the human glutaredoxin gene (HGMW-approved symbol GLRX) has recently been isolated and cloned from a human fetal spleen cDNA library. The screening of a human genomic library in Charon 4A led to the identification of three genomic clones. Using fluorescence in situ hybridization to metaphase chromosomes with one genomic clone as a probe, the human glutaredoxin gene was localized to chromosomal region 5q14. This localization at chromosome 5 was in agreement with the somatic cell hybrid analysis, using DNA from a human-hamster and a human-mouse hybrid panel and using a human glutaredoxin cDNA as a probe. |
| Databáze: | OpenAIRE |
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