Antimutagenic efficacy of higher doses of vitamin C
| Autor: | Parimal Kumar Khan, S. P. Sinha |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Vitamin
Mitosis Bone Marrow Cells Mice Inbred Strains Ascorbic Acid Pharmacology Toxicology medicine.disease_cause Mice chemistry.chemical_compound Therapeutic index Genetics Animals Medicine Mancozeb Chromosome Aberrations Zineb Vitamin C business.industry Phosphamidon Antimutagenic Agents Ascorbic acid chemistry Mutagenesis Maneb business Antimutagen Endosulfan Genotoxicity |
| Zdroj: | Mutation Research/Genetic Toxicology. 298:157-161 |
| ISSN: | 0165-1218 |
| Popis: | Vitamin C, when administered concurrently with a pesticide (endosulfan, phosphamidon or mancozeb), could significantly decrease the frequency of pesticide-induced clastogenic and mitosis-disruptive changes in the bone marrow cells of young Swiss albino mice. Of the three doses (10, 20 or 40 mg/kg b.wt./day) of the vitamin, the one which is double the human therapeutic dose (20 mg/kg b.wt./day) was most effective as an antimutagen to be followed by 40 mg and 10 mg. None of these doses of vitamin C showed any genotoxicity of their own for the parameters studied here. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|