Immunochemical studies and complete amino acid sequence of the streptokinase from Streptococcus pyogenes (group A) M type 12 strain A374
| Autor: | N Kotani, K H Johnston, A Tsugita, K Horiuchi, N Shikama, M Mizuse, H. Ohkuni, Yuko Todome, H. Suzuki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1992 |
| Předmět: |
medicine.drug_class
Streptococcus pyogenes Immunology Blotting Western Molecular Sequence Data Sequence alignment Biology Monoclonal antibody medicine.disease_cause Microbiology Group A Epitope Epitopes Sequence Homology Nucleic Acid medicine Streptokinase Amino Acid Sequence Amino Acids Peptide sequence chemistry.chemical_classification Chromosome Mapping Streptococcaceae biology.organism_classification Molecular biology Amino acid Infectious Diseases chemistry Parasitology Electrophoresis Polyacrylamide Gel Research Article |
| Popis: | The complete amino acid sequence of the streptokinase (SKase) of Streptococcus pyogenes M type 12 strain A374, isolated from a patient with poststreptococcal glomerulonephritis (PSGN), was determined. The epitope domain for the monoclonal antibody N-59, which cross-reacts with SKases of both the PSGN-associated strain and S. equisimilis H46A (a non-PSGN-associated strain), was predicted to be localized in residues 370 to 374. The epitope domain specific for monoclonal antibody RU-1, which reacts only with the PSGN-associated SKase, was localized to residues 164 to 236. |
| Databáze: | OpenAIRE |
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