Biomarkers of vascular injury in relation to myocardial infarction risk: A population-based study
Autor: | Peter Bugert, Laura Pletsch-Borba, Disorn Sookthai, Manja Kloss, Theron Johnson, Sandra González Maldonado, Tilman Kühn, Mirja Grafetstätter, Rudolf Kaaks, Marie Luise Groß, Anika Hüsing |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Population lcsh:Medicine Fibrinogen Article 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine medicine Myocardial infarction education lcsh:Science education.field_of_study Multidisciplinary business.industry Proportional hazards model Hazard ratio lcsh:R medicine.disease 030104 developmental biology Cohort Biomarker (medicine) lcsh:Q business 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Little is known about circulating biomarkers of vascular injury in relation to cardiovascular disease risk. Thus, we evaluated associations between six novel markers (E-Selectin, P-Selectin, thrombomodulin, thrombopoietin, intercellular adhesion molecule 3 and GPIIb/IIIa) and established cardiovascular risk factors as well as the risk of myocardial infarction (MI) in a population-based study. Biomarkers were measured in pre-diagnostic plasma samples of a case-cohort subset of EPIC-Heidelberg (incident MI cases: n = 369, random sub-cohort: n = 2,418). Generalized Linear models were used to analyse cross-sectional associations between biomarkers and cardiovascular risk factors. Multivariable Cox Regression analyses were carried out to obtain Hazard Ratios (HRs) of MI across quartiles of biomarkers levels. Cross-sectional analyses showed that sex, smoking, alcohol consumption, diabetes and exogenous hormone use were associated with biomarker levels. However, while fibrinogen was associated with MI risk (HR per standard deviation: 2.97 [95% confidence interval: 1.61, 5.46]), none of the six novel biomarkers was associated with MI risk after multivariable adjustment. In a population-based cohort, biomarkers of vascular injury were associated with established cardiovascular risk factors, but not MI risk. The tested biomarkers may reflect pathophysiological alterations in cardiovascular disease development rather than constituting independent MI risk factors. |
Databáze: | OpenAIRE |
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