Survival benefit of lobectomy for glioblastoma: moving towards radical supramaximal resection
| Autor: | Veronica Borowy, Alexander D. Sanjurjo, Michael E. Ivan, Evan Luther, Macarena I. de la Fuente, Ricardo J. Komotar, Long Di, Javier Figueroa, Ashish H. Shah, Daniel G Eichberg, Anil K. Mahavadi, Alexa Semonche |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Brain tumor Fluid-attenuated inversion recovery Article Neurosurgical Procedures Lesion 03 medical and health sciences 0302 clinical medicine Glioma medicine Humans Survival analysis Aged Retrospective Studies business.industry Brain Neoplasms Middle Aged medicine.disease Prognosis Surgery Survival Rate Neurology Oncology 030220 oncology & carcinogenesis Cohort Propensity score matching Female Neurology (clinical) medicine.symptom business Complication Glioblastoma 030217 neurology & neurosurgery Craniotomy Follow-Up Studies |
| Zdroj: | J Neurooncol |
| Popis: | PURPOSE: Extent of resection remains a paramount prognostic factor for long-term outcomes for glioblastoma. As such, supramaximal resection or anatomic lobectomy have been offered for non-eloquent glioblastoma in an attempt to improve overall survival. Here, we conduct a propensity-matched analysis of patients with non-eloquent glioblastoma who underwent either lobectomy or gross total resection of lesion to investigate the efficacy of supramaximal resection of glioblastoma. METHODS: Patients who underwent initial surgery for gross total resection or lobectomy for non-eloquent glioblastoma at our tertiary care referral center from 2010-2019 were included for this propensity-matched survival analysis. Propensity scores were generated with the following covariates: age, location, preoperative KPS, product of perpendicular maximal tumor diameters, and product of perpendicular FLAIR signal diameters. Inverse probability of treatment weighting (IPTW) with generated propensity scores was used to compare progression-free survival and overall survival. RESULTS: Sixty-nine patients were identified who underwent initial resection of glioblastoma for non-eloquent glioblastoma from 2010-2019 (GTR=37, lobectomy=32). Using IPTW, overall survival (30.7 vs. 14.1 months) and progression-free survival (17.2 vs. 8.1 months were significantly higher in the lobectomy cohort compared to the GTR group (p |
| Databáze: | OpenAIRE |
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