Surgical Management of Hyperinsulinism in the Multiple Endocrine Neoplasia, Type 1 Syndrome
| Autor: | Clive S. Grant, Robert L. Telander, J. Aidan Carney, Dennis A. Rasbach, Jon A. van Heerden |
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| Rok vydání: | 1985 |
| Předmět: |
Adenoma
Adult Male medicine.medical_specialty Adolescent medicine.medical_treatment Enucleation Postoperative Complications Hyperinsulinism medicine Carcinoma Humans Child Multiple endocrine neoplasia Retrospective Studies medicine.diagnostic_test business.industry Multiple Endocrine Neoplasia Retrospective cohort study Middle Aged Adenoma Islet Cell medicine.disease Surgery Pancreatic Neoplasms Pancreatectomy Angiography Female business |
| Zdroj: | Archives of Surgery. 120:584 |
| ISSN: | 0004-0010 |
| DOI: | 10.1001/archsurg.1985.01390290062010 |
| Popis: | • We retrospectively reviewed the records of 12 patients from one institution (from 1970 through 1983) who had hyperinsulinism as a part of the multiple endocrine neoplasia, type 1 syndrome. All of the patients underwent surgical exploration: ten had subtotal pancreatectomies, one had enucleation, and one underwent a total pancreatectomy. There was no operative mortality. Preoperative and intraoperative localization studies (angiography and ultrasonography) tended to underestimate the number of pancreatic tumors. Ten patients had multiple B-cell adenomas (mean, 7.4), while two patients had single tumors. This study confirms that hyperinsulinism, when it occurs as part of the multiple endocrine neoplasia, type 1 syndrome, is usually due to multiple islet cell tumors, and that the islet cell tissue is probably diffusely dysplastic. Subtotal (85%) pancreatectomy is suggested as the procedure of choice for this subgroup of patients with hyperinsulinism. ( Arch Surg 1985;120:584-589) |
| Databáze: | OpenAIRE |
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