Postprandial gastric antral contractions in patients with gastro-oesophageal reflux disease: a scintigraphic study
| Autor: | Marie Secaf, Luiz Ernesto de Almeida Troncon, Roberto Oliveira Dantas, Eder Rezende Moraes, José Ruver L. Herculano, C. L. A. Barbieri, Lilian Rose Otoboni Aprile |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Physiology Gastric motility Scintigraphy digestive system Gastroenterology Internal medicine Pyloric Antrum Humans Medicine Ingestion Radionuclide Imaging Antrum medicine.diagnostic_test Gastric emptying Endocrine and Autonomic Systems business.industry Stomach digestive oral and skin physiology Reflux Middle Aged Postprandial Period digestive system diseases Postprandial Gastric Emptying Gastroesophageal Reflux Female Peristalsis business Muscle Contraction Half time |
| Zdroj: | Neurogastroenterology & Motility. 20:471-478 |
| ISSN: | 1365-2982 1350-1925 |
| DOI: | 10.1111/j.1365-2982.2007.01067.x |
| Popis: | Disturbed gastric contractility has been found in manometric studies in patients with gastro-oesophageal reflux disease (GORD), but the pathophysiological role of this abnormality is unclear. We aimed at assessing postprandial gastric antral contractions and its relationships with gastric emptying and gastro-oesophageal reflux in GORD patients. Fasted GORD patients (n = 13) and healthy volunteers (n = 13) ingested a liquid meal labelled with 72 MBq of 99mTechnetium-phytate. Gastric images were acquired every 10 min for 2 h, for measuring gastric emptying half time. Dynamic antral scintigraphy (one frame per second), performed for 4 min at 30-min intervals, allowed estimation of both mean dominant frequency and amplitude of antral contractions. In GORD patients (n = 10), acidic reflux episodes occurring 2 h after the ingestion of the same test meal were determined by ambulatory 24-h oesophageal pH monitoring. Gastric emptying was similar in GORD patients and controls (median; range: 82 min; 58-126 vs 80 min; 44-122 min; P = 0.38). Frequency of antral contractions was also similar in both groups (3.1 cpm; 2.8-3.6 vs 3.2 cpm; 2.4-3.8 cpm; P = 0.15). In GORD patients, amplitude of antral contractions was significantly higher than in controls (32.7%; 17-44%vs 23.3%; 16-43%; P = 0.01), and correlated positively with gastric emptying time (R(s) = 0.58; P = 0.03) and inversely with the number of reflux episodes (R(s) = -0.68; P = 0.02). Increased amplitude of postprandial gastric antral contractions in GORD may comprise a compensatory mechanism against delayed gastric emptying and a defensive factor against acidic gastro-oesophageal reflux. |
| Databáze: | OpenAIRE |
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