Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders
| Autor: | Ali Dakroub, Assaad A. Eid, Yusra Al-Dhaheri, Suzanne A. Nasser, Humna Bhagani, Gianfranco Pintus, Ali H. Eid, Nour K. Younis, Ahmed F. El-Yazbi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
NAD+ Nicotinamide phosphoribosyltransferase 030209 endocrinology & metabolism Review CD38 Biology Models Biological PARPs/MARTs 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine sirtuins Biosynthesis Metabolic Diseases Extracellular Animals Humans metabolic disorders Nicotinamide Phosphoribosyltransferase lcsh:QH301-705.5 chemistry.chemical_classification Clinical Trials as Topic visfatin/NAMPT General Medicine NAD Cell biology 030104 developmental biology Enzyme chemistry lcsh:Biology (General) Cardiovascular Diseases NAD+ kinase Signal transduction Intracellular |
| Zdroj: | Cells Cells, Vol 9, Iss 2444, p 2444 (2020) |
| ISSN: | 2073-4409 |
| Popis: | Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) is an adipocytokine with several intriguing properties. It was first identified as pre-B-cell colony-enhancing factor but turned out to possess enzymatic functions in nicotinamide adenine dinucleotide biosynthesis, with ubiquitous expression in skeletal muscles, liver, cardiomyocytes, and brain cells. Visfatin exists in an intracellular (iNAMPT) and extracellular (eNAMPT) form. Intracellularly, visfatin/iNAMPT plays a regulatory role in NAD+ biosynthesis and thereby affects many NAD-dependent proteins such as sirtuins, PARPs, MARTs and CD38/157. Extracellularly, visfatin is associated with many hormone-like signaling pathways and activates some intracellular signaling cascades. Importantly, eNAMPT has been associated with several metabolic disorders including obesity and type 1 and 2 diabetes. In this review, a brief overview about visfatin is presented with special emphasis on its relevance to metabolic diseases. Visfatin/NAMPT appears to be a unique molecule with clinical significance with a prospective promising diagnostic, prognostic, and therapeutic applications in many cardiovasculo-metabolic disorders. |
| Databáze: | OpenAIRE |
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