Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia
| Autor: | Damle, R. N., Wasil, T., Fais, F., Fabio Ghiotto, Valetto, A., Allen, S. L., Buchbinder, A., Budman, D., Dittmar, K., Kolitz, J., Lichtman, S. M., Schulman, P., Vinciguerra, V. P., Rai, K. R., Ferrarini, M., Chiorazzi, N. |
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| Rok vydání: | 1999 |
| Předmět: |
Male
B-Lymphocytes Time Factors Genes Immunoglobulin Immunology Immunoglobulin Variable Region Cell Biology Hematology CD5 Antigens Prognosis Leukemia Lymphocytic Chronic B-Cell Survival Analysis Biochemistry Immunophenotyping Cohort Studies Antigens CD immune system diseases hemic and lymphatic diseases Mutation Humans Female Immunoglobulin Light Chains Follow-Up Studies |
| Zdroj: | Scopus-Elsevier Europe PubMed Central FRANCO FAIS |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | Cellular immunophenotypic studies were performed on a cohort of randomly selected IgM+ B-chronic lymphocytic leukemia (B-CLL) cases for which Ig VH and VL gene sequences were available. The cases were categorized based on V gene mutation status and CD38 expression and analyzed for treatment history and survival. The B-CLL cases could be divided into 2 groups. Those patients with unmutated V genes displayed higher percentages of CD38+ B-CLL cells (≥30%) than those with mutated V genes that had lower percentages of CD38+ cells ( |
| Databáze: | OpenAIRE |
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