Cytomegalovirus retinitis and AIDS in Edinburgh
| Autor: | David Eddyshaw, Hunter Maclean, Ray Brettle, Baljean Dhillon, Izham Cheong, P J Flegg |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Foscarnet
Ganciclovir Adult Male medicine.medical_specialty Blood transfusion Visual acuity genetic structures medicine.medical_treatment Dermatology Fundus (eye) 03 medical and health sciences 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) Recurrence Ophthalmology medicine Humans Pharmacology (medical) 030212 general & internal medicine 030505 public health AIDS-Related Opportunistic Infections business.industry Public Health Environmental and Occupational Health Retinal detachment medicine.disease eye diseases Infectious Diseases Treatment Outcome Scotland Cytomegalovirus Retinitis Female Cytomegalovirus retinitis medicine.symptom 0305 other medical science business medicine.drug Follow-Up Studies |
| Zdroj: | International journal of STDAIDS. 4(6) |
| ISSN: | 0956-4624 |
| Popis: | The medical records, retinal drawings and fundus photographs of all patients with cytomegalovirus retinitis (CMVR) and AIDS in Edinburgh between 1986–1992 were reviewed to determine the efficacy of treatment in preserving vision. Ophthalmoscopic features of CMVR were observed in 32 eyes of 24 patients with AIDS, 19 males and 5 females. HIV transmission in this group was by homo/bisexual contact (16), injection drug use (7) and blood transfusion (1). Unilateral blurring was the commonest visual symptom although 9 (38%) patients had no visual symptoms. All patients presented with a corrected visual acuity of 6/12 or better in at least one eye. Following treatment with systemic ganciclovir or foscarnet 16 patients (66%) developed toxic side-effects of therapy and 13 (54%) experienced a recurrence of CMVR. Four (17%) patients developed a retinal detachment in one eye. The mean survival was 8.3 months after the diagnosis of CMVR. At final follow-up, between 2–26 months after the diagnosis of CMVR, 21 (87.5%) patients retained useful vision (6/18 or better) although 3 (12.5%) were effectively blind (less than 6/60). We conclude that with prompt diagnosis and treatment of CMVR vision can be preserved in the majority of cases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|