Sphingosines Derived from Marine Sponge as Potential Multi-Target Drug Related to Disorders in Cancer Development
| Autor: | João Luís Carraro, Roger R. Dresch, Douglas F. Rambo, Mário L C da Frota Junior, Renata Biegelmeyer, Rafael Schröder, Beatriz Mothes, José Cláudio Fonseca Moreira, Amélia T. Henriques |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Antioxidant
antioxidant Cell Survival medicine.medical_treatment H. tubifera Pharmaceutical Science Antineoplastic Agents Biology Article Antioxidants cytotoxic Neuroblastoma Haliclona Sphingosine Cell Line Tumor Drug Discovery medicine Animals Humans lcsh:QH301-705.5 Pharmacology Toxicology and Pharmaceutics (miscellaneous) IC50 Blood Coagulation chemistry.chemical_classification Reactive oxygen species Sphingolipids Molecular Structure anticoagulant Cancer Glioma biology.organism_classification medicine.disease Sphingolipid In vitro Porifera Sponge lcsh:Biology (General) Biochemistry chemistry sphingosines |
| Zdroj: | Marine Drugs Volume 13 Issue 9 Pages 5552-5563 Marine Drugs, Vol 13, Iss 9, Pp 5552-5563 (2015) |
| ISSN: | 1660-3397 |
| Popis: | Haliclona tubifera, marine sponge species abundant in Brazilian coastline, presents only a few papers published in the literature. Recently, we have reported the isolation of two modified C18 sphingoid bases: (2R,3R,6R,7Z)-2-aminooctadec-7-ene-1,3, 6-triol and and (2R,3R,6R)-2-aminooctadec-1,3,6-triol. In order to continue our research, in this work aimed at the biological investigation of fractions that led to the isolation of these compounds. We evaluated the cytotoxic effect of marine sponge H. tubifera fractions in glioma (U87) and neuroblastoma (SH-SY5Y) human cell lines. In addition, considering the link between cancer, imbalance of reactive oxygen species and coagulation disorders, we also investigated the in vitro effects on blood coagulation and their redox properties. We showed that the ethyl acetate (EtOAc) fraction, rich in sphingoid bases, had important cytotoxic effects in both cancer cell lines with an IC50 < 15 μg/mL and also can inhibit the production of peroxyl radicals. Interestingly, this fraction increased the recalcification time of human blood, showing anticoagulant properties. The present study indicates the sphingosines fraction as a promising source of chemical prototypes, especially multifunctional drugs in cancer therapy. |
| Databáze: | OpenAIRE |
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