Age-Related Changes in Enzymes of Rat Brain
| Autor: | Greenbaum Al, Hothersall Js, El-Hassan A, P. McLean |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Glutathione reductase Malic enzyme Dehydrogenase Pentose phosphate pathway Redox Biochemistry chemistry.chemical_compound Age related Internal medicine medicine Glycolysis Hydrogen peroxide chemistry.chemical_classification Hexokinase biology Chemistry Glutathione peroxidase Hydrogen transfer Glutathione Metabolism Rat brain Citric acid cycle Endocrinology Enzyme Lipogenesis biology.protein Flux (metabolism) Peroxidase |
| Zdroj: | Enzyme. 27:130-136 |
| ISSN: | 2504-2564 0013-9432 |
| DOI: | 10.1159/000459037 |
| Popis: | Measurements have been made of the activity of the enzymes of the glycolytic, pentose phosphate and lipogenic pathways and of some marker enzymes of the tricarboxylic acid cycle in brains of rats aged between 20 days and 24 months. In general, the activity of the most enzymes measured was unchanged by aging but exceptions to this were increases of hexokinase, glucose-6-phosphate dehydrogenase and 'malic enzyme' and decreases of ATP-citrate lyase, acetyl-CoA carboxylase and fatty acid synthetase. An exceptionally large (2-fold) increase in the activity of cytosolic glycerol 3-phosphate dehydrogenase was noted. These changes are considered in relation to the overall metabolic activity of the brain. |
| Databáze: | OpenAIRE |
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