GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis

Autor: Yang De Marinis, Stefan Amisten, Patrik Rorsman, Yusuke Moritoh, Tadao Shibasaki, Martin Bengtsson, Susumu Seino, Reshma Ramracheya, Quan Zhang, Orit Braha, Enming Zhang, Fernando Abdulkader, Albert Salehi, Erik Renström, Matthias Braun, Fiona M. Gribble, Frank Reimann, Caroline E. Ward, Lena Eliasson, Abdella M. Habib, Anders Rosengren
Jazyk: angličtina
Rok vydání: 2016
Předmět:
medicine.medical_specialty
endocrine system
Calcium Channels
L-Type
Epinephrine
Physiology
HUMDISEASE
030209 endocrinology & metabolism
Biology
Glucagon
Exocytosis
Article
Alpha cell
Membrane Potentials
Islets of Langerhans
Mice
03 medical and health sciences
chemistry.chemical_compound
Calcium Channels
N-Type
0302 clinical medicine
Glucagon-Like Peptide 1
Internal medicine
Cyclic AMP
medicine
Animals
Guanine Nucleotide Exchange Factors
Receptor
Molecular Biology
Cells
Cultured
030304 developmental biology
0303 health sciences
Forskolin
Colforsin
digestive
oral
and skin physiology
Glucagon secretion
Cell Biology
Cyclic AMP-Dependent Protein Kinases
Mice
Inbred C57BL
FISIOLOGIA
Somatostatin
Endocrinology
chemistry
SIGNALING
Carrier Proteins
Cell and Molecular Biology
Intracellular
hormones
hormone substitutes
and hormone antagonists
Zdroj: Cell Metabolism; 11(6), pp 543-553 (2010)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ISSN: 1550-4131
Popis: Glucagon secretion is inhibited by glucagon-like peptide-1 (GLP-1) and stimulated by adrenaline. These opposing effects on glucagon secretion are mimicked by low (1-10 nM) and high (10 muM) concentrations of forskolin, respectively. The expression of GLP-1 receptors in alpha cells is
Databáze: OpenAIRE
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