6-shogaol induces apoptosis and enhances radiosensitivity in head and neck squamous cell carcinoma cell lines
| Autor: | Ulana Kotowski, Gregor Heiduschka, Dietmar Thurnher, Elisabeth Foki, Sven Schneider, Lorenz Kadletz, Rudolf Seemann, Rainer Schmid |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Catechols Apoptosis Ginger 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Line Tumor Survivin medicine Humans Viability assay Radiosensitivity Aged Pharmacology Cisplatin Plant Extracts Chemistry Head and neck cancer Shogaol Middle Aged medicine.disease Head and neck squamous-cell carcinoma 030104 developmental biology Head and Neck Neoplasms 030220 oncology & carcinogenesis Carcinoma Squamous Cell Cancer research medicine.drug |
| Zdroj: | Phytotherapy Research. 32:340-347 |
| ISSN: | 0951-418X |
| DOI: | 10.1002/ptr.5982 |
| Popis: | Ginger (Zingiber officinale Roscoe) is used for a wide array of conditions in traditional medicine in Asia, but little is known about the effect on head and neck cancer. In this study, the effect of two major pharmacologically active compounds of ginger, 6-gingerol and 6-shogaol, were studied on head and neck cancer cell lines. Furthermore, experiments in combination with established treatment methods for head and neck cancer were performed. Proliferation assays showed a dose-dependent reduction of cell viability. Flow cytometry analysis revealed the induction of apoptosis. Western blot analysis indicated that the antiapoptotic protein survivin was suppressed after treatment. Although a combination of 6-shogaol with cisplatin exhibited no synergistic effect, the combination with irradiation showed a synergistic reduction of clonogenic survival. In conclusion, ginger compounds have many noteworthy effects on head and neck cancer cell lines. In particular, the enhancement of radiosensitivity is remarkable. |
| Databáze: | OpenAIRE |
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