Prevalence of Walking-Related Motor Fatigue in Persons With Multiple Sclerosis:Decline in Walking Distance Induced by the 6-Minute Walk Test
| Autor: | E. Jensen, Ilse Baert, Kathy Knuts, Carmen Santoyo Medina, Anders Guldhammer Skjerbæk, Vendula Doležalová, Francois Bethoux, Joanne M. Wagner, Ulrik Dalgas, Benoit Gebara, Deborah Severijns, Carmela Leone, Peter Feys, Benoit Maertens de Noordhout, Anders Romberg, Kamila Rasova, Heigo Maamâgi |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 030506 rehabilitation medicine.medical_specialty Multiple Sclerosis Walking motor fatigue Primary progressive 03 medical and health sciences Walking distance walking 0302 clinical medicine Physical medicine and rehabilitation Prevalence medicine Humans 6-minute walk test Clinical phenotype Secondary progressive Fatigue deceleration index Expanded Disability Status Scale distance walked index Multiple sclerosis General Medicine Middle Aged medicine.disease Cross-Sectional Studies Walk test Exercise Test Physical therapy Female 0305 other medical science Psychology 030217 neurology & neurosurgery |
| Zdroj: | Leone, C, Severijns, D, Doležalová, V, Baert, I, Dalgas, U, Romberg, A, Bethoux, F, Gebara, B, Santoyo Medina, C, Maamâgi, H, Rasova, K, Maertens de Noordhout, B, Knuts, K, Skjerbaek, A, Jensen, E, Wagner, J M & Feys, P 2016, ' Prevalence of Walking-Related Motor Fatigue in Persons With Multiple Sclerosis : Decline in Walking Distance Induced by the 6-Minute Walk Test ', Neurorehabilitation and Neural Repair, vol. 30, no. 4, pp. 373-383 . https://doi.org/10.1177/1545968315597070 |
| Popis: | Objective. To investigate the individual occurrence of walking-related motor fatigue in persons with multiple sclerosis (PwMS), according to disability level and disease phenotype. Study design. This was a cross-sectional, multinational study. Participants. They were 208 PwMS from 11 centers with Expanded Disability Status Scale (EDSS) scores up to 6.5. Methods. The percentage change in distance walked (distance walked index, DWI) was calculated between minute 6 and 1 (DWI6-1) of the 6-Minute Walk Test (6MWT). Its magnitude was used to classify participants into 4 subgroups: (1) DWI6-1[≥5%], (2) DWI6-1[5%; –5%], (3) DWI6-1[–5%; > –15%], and (4) DWI6-1[≤−15%]. The latter group was labeled as having walking-related motor fatigue. PwMS were stratified into 5 subgroups based on the EDSS (0-2.5, 3-4, 4.5-5.5, 6, 6.5) and 3 subgroups based on MS phenotype (relapsing remitting [RR], primary progressive [PP], and secondary progressive [SP]). Results. The DWI6-1 was ≥5% in 16 PwMS (7.7%), between 5% and −5% in 70 PwMS (33.6%), between −5% and −15% in 58 PwMS (24%), and ≤−15% in 64 PwMS (30.8%). The prevalence of walking-related motor fatigue (DWI6-1[≤−15%]) was significantly higher among the progressive phenotype (PP = 50% and SP = 39%; RR = 15.6%) and PwMS with higher disability level (EDSS 4.5-5.5 = 48.3%, 6 = 46.3% and 6.5 = 51.5%, compared with EDSS 0-2.5 = 7.8% and 3-4 = 16.7%; P < .05). Stepwise multiple regression analysis indicated that EDSS, but not MS phenotype, explained a significant part of the variance in DWI6-1 ( R2 = 0.086; P < .001). Conclusion. More than one-third of PwMS showed walking-related motor fatigue during the 6MWT, with its prevalence greatest in more disabled persons (up to 51%) and in those with progressive MS phenotype (up to 50%). Identification of walking-related motor fatigue may lead to better-tailored interventions. |
| Databáze: | OpenAIRE |
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