Non-alcoholic Fatty Liver Disease Is a Risk Factor for Type 2 Diabetes in Middle-aged Japanese Men and Women
| Autor: | Katsuyuki Nakajima, Masako Akuzawa, Yoshiharu Tokita, Nobuyoshi Ishiyama, Seiichi Takenoshita, Yohnosuke Shimomura, Yuko Maejima, Kenju Shimomura |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Population 030209 endocrinology & metabolism Type 2 diabetes Gastroenterology Impaired glucose tolerance 03 medical and health sciences 0302 clinical medicine Japan Non-alcoholic Fatty Liver Disease Risk Factors Diabetes mellitus Internal medicine Type 2 diabetes mellitus Internal Medicine Medicine Humans health check for 10-year follow up Risk factor Sex Distribution education education.field_of_study business.industry Incidence Fatty liver Type 2 Diabetes Mellitus General Medicine ultrasonography Middle Aged medicine.disease Diabetes Mellitus Type 2 Relative risk Regression Analysis 030211 gastroenterology & hepatology Original Article Female business non-alcoholic fatty liver disease (NAFLD) |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | Objective Emerging studies have focused on the association between non-alcoholic fatty liver disease (NAFLD) and the risk of type 2 diabetes mellitus (T2DM). We aimed to investigate whether NAFLD diagnosed by ultrasonography could predict the risk of future T2DM in a Japanese middle-aged health check population. Methods We conducted a 10-year observational study in a health checkup population of middle-aged Japanese men and women at Hidaka Hospital from 2004 to 2013. We excluded cases with an alcohol intake exceeding 20 g/day and those with impaired glucose tolerance. The remaining 1,544 men and 864 women were classified into fatty liver and non-fatty liver groups based on the findings of abdominal ultrasonography. Both groups were followed for the development of diabetes. A multiple regression analysis was performed for each variable to predict the risk of future diabetes. Results The median age of the participants was 46.0 years at the entry, and the follow-up period was 10 years. The incidence of diabetes in the fatty liver group was 12.5% (29/232) in men and 26.3% (10/38) in women, whereas the incidence of diabetes in the non-fatty liver group was 2.5% (34/1,312) in men and 1.8% (15/826) in women. The relative risk of diabetes associated with fatty liver was 4.8 [95% confidence interval (CI) 3.0 -7.8, p |
| Databáze: | OpenAIRE |
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