Change in disability profile and quality of life in multiple sclerosis patients: a five-year longitudinal study using the Multiple Sclerosis Impact Profile (MSIP)

Autor: A. T. van Wijlen, Klaske Wynia, S. A. Reijneveld, Berrie Middel, J. F. Meilof
Přispěvatelé: Faculteit Medische Wetenschappen/UMCG, Science in Healthy Ageing & healthcaRE (SHARE), Public Health Research (PHR)
Rok vydání: 2011
Předmět:
Male
Longitudinal study
Time Factors
Disease
FATIGUE
Severity of Illness Index
DISEASE
Disability Evaluation
Sickness Impact Profile
HISTORICAL PROSPECTIVE COHORT
Longitudinal Studies
Young adult
POPULATION
Depression (differential diagnoses)
Netherlands
Aged
80 and over
education.field_of_study
longitudinal study
Middle Aged
DEPRESSION
Prognosis
Neurology
Disease Progression
Female
CHRONIC PAIN
Adult
medicine.medical_specialty
Multiple Sclerosis
Population
Young Adult
Multiple Sclerosis Impact Profile
Physical medicine and rehabilitation
Quality of life (healthcare)
Predictive Value of Tests
Severity of illness
medicine
Humans
education
Aged
business.industry
Multiple sclerosis
SOCIAL-CONSEQUENCES
NATURAL-HISTORY
OUTCOME MEASURES
medicine.disease
mortality
disability
Physical therapy
Quality of Life
Neurology (clinical)
business
SCALE MSIS-29
Follow-Up Studies
Zdroj: Multiple sclerosis journal, 18(5), 654-661. SAGE Publications Inc.
ISSN: 1477-0970
1352-4585
Popis: Background: Evidence on the progress of disease severity in Multiple Sclerosis (MS) is generally limited in scope. Objectives: To examine the course of a broad spectrum of MS-related disabilities and quality of life (QOL) in relation to disease severity, and responsiveness of the Multiple Sclerosis Impact Profile (MSIP). Methods: The mortality rate was calculated after checking the national population register for vital status of the initial cohort. We performed a longitudinal study among 245 patients with MS attending the Groningen MS Center in the Netherlands. We assessed these patients in 2004 and 2009 using a postal survey including the MSIP to evaluate disabilities, the World Health Organization Quality of Life-Abbreviation version (WHOQOL-BREF) to evaluate QOL, and the ambulation question of the Expanded Disability Status Scale (EDSS) to evaluate disease severity. Responsiveness of the MSIP was estimated using standardized response mean (SRM). Results: Increase of disability in the MSIP disability domains and loss of QOL were most prevalent and pronounced in patients with EDSS 0 to < 4.5 in 2004. MSIP and QOL scores were remarkably stable in the higher disease severity groups. Mortality rates were highest (24%) in patients with EDSS ≥ 7 to < 10 in 2004. SRM indices for the MSIP ranged between 0.26 and 0.56. Conclusions: Prominent increases in multiple aspects of disability and loss of QOL occur especially in the early stages in MS. Health care interventions may lead to health and QOL gains, in particular when offered to patients in the first stage of the MS process. Responsiveness was sufficient for nine of the 11 MSIP domains.
Databáze: OpenAIRE
Externí odkaz: