| Autor: |
Jaqueline Vaz Vanini, Leonardo Kenji Sakaue Koyama, Leandro Luongo de Matos, José Martins Figueredo Junior, Claudio Roberto Cernea, Cibele Pidorodeski Nagano, Cláudia Malheiros Coutinho-Camillo, Ricardo Hsieh, Silvia Vanessa Lourenço |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of bone oncology. 33 |
| ISSN: |
2212-1366 |
| Popis: |
Bone invasion is an important prognostic factor in oral squamous cell carcinoma, leading to a lower survival rate and the use of aggressive treatment approaches. Epithelial-mesenchymal transition (EMT) is possibly involved in this process, because it is often related to mechanisms of cell motility and invasiveness. This study examined whether a panel of epithelial-mesenchymal markers are present in cases of oral squamous cell carcinoma with bone invasion and whether these proteins have any relationship with patients' clinical-pathological parameters and prognostic factors.Immunohistochemical analysis of E-cadherin,The analysis revealed that most cases (66%) presented with a dominant tumor infiltrative pattern in bone tissue, associated with lower survival rates, when compared with cases with a dominant erosive invasion pattern (P = 0.048). Twenty-seven cases (43%) expressed markers that were compatible with total or partial EMT at the tumor-bone interface. There was no association between evidence of total or partial EMT and other demographic or prognostic features. E-cadherin-positive cases were associated with tobacco smoking (P = 0.022); vimentin-positive cases correlated with tumors under 4 cm (P = 0.043).We observed evidence of total or partial EMT in oral squamous cell carcinoma bone invasion. The transcription factor |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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