RGD-targeted redox responsive nano micelle: co-loading docetaxel and indocyanine green to treat the tumor
Autor: | Yaning Li, Guoguang Chen, Jun Yin, Jie Wei, Junfang Nie, Xiaolong Yang, Lili Ren |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Indocyanine Green
Combination therapy Photothermal Therapy Chemistry Pharmaceutical Polyesters medicine.medical_treatment Pharmaceutical Science Antineoplastic Agents Docetaxel RM1-950 Micelle redox responsive Polyethylene Glycols combination therapy Mice chemistry.chemical_compound Drug Stability Case fatality rate medicine Animals Micelles Cell Size Drug Carriers Mice Inbred BALB C Chemotherapy Cancer General Medicine Phototherapy Redox responsive medicine.disease polymer micelles Drug Liberation chemistry Cancer research Nanoparticles rgd peptide Therapeutics. Pharmacology Oligopeptides Indocyanine green Research Article medicine.drug |
Zdroj: | Drug Delivery, Vol 28, Iss 1, Pp 2024-2032 (2021) Drug Delivery article-version (VoR) Version of Record |
ISSN: | 1521-0464 1071-7544 |
Popis: | Cancer, also known as a malignant tumor, has developed into a type of disease with the highest fatality rate, seriously threatening the lives and health of people. Chemotherapy is one of the most important methods for the treatment of cancer. However, chemotherapy drugs have some problems, such as low solubility and lack of targeting, which severely limit their clinical applications. To solve these problems, we designed a block copolymer that has a disulfide bond response. The polymer uses RGD peptide (arginine-glycine-aspartic acid) as the active targeting group, PEG (polyethylene glycol) as the hydrophilic end, and PCL (polycaprolactone) as the hydrophobic end. Then we utilized the amphiphilic polymer as a carrier to simultaneously deliver DOC (docetaxel) and ICG (indocyanine green), to realize the combined application of chemotherapy and photothermal therapy. The antitumor efficacy in vivo and histology analysis showed that the DOC/ICG-loaded micelle exhibited higher antitumor activity. The drug delivery system improved the solubility of DOC and the stability of ICG, realized NIR-guided photothermal therapy, and achieved an ideal therapeutic effect. |
Databáze: | OpenAIRE |
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