Role of vagal afferents in vasodepressor effects of PGE2 in spontaneously hypertensive rats
| Autor: | D. S. Chen, D. E. Donald, J. C. Romero |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
medicine.medical_specialty Physiology Microgram medicine.medical_treatment Blood Pressure Vagotomy Renovascular hypertension Physiology (medical) Jugular vein Internal medicine Vasoactive medicine Animals Afferent Pathways Dose-Response Relationship Drug business.industry Prostaglandins E Vagus Nerve medicine.disease Rats Endocrinology Blood pressure Lower threshold Anesthesia Hypertension Reflex Rabbits Cardiology and Cardiovascular Medicine business |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 236:H635-H639 |
| ISSN: | 1522-1539 0363-6135 |
| DOI: | 10.1152/ajpheart.1979.236.4.h635 |
| Popis: | In anesthetized, spontaneously hypertensive rats (Okamoto-Aoki), injections of 0.75, 1.5, and 3.0 microgram/kg PGE2 into the jugular vein caused transient decreases (mean +/- SE) in arterial pressure of 21 +/- 2, 37 +/- 3, and 78 +/- 6 mmHg, respectively, before cervical vagotomy and of 1 +/- 1, 15 +/- 4, and 15 +/- 6 mmHg after cervical vagotomy. The vasodepressor effect of jugular vein injections of 3.0 microgram/kg PGE2, but not of lower doses, was depressed by vagotomy in normotensive Wistar-Kyoto and Sprague-Dawley rats. Vagotomy did not reduce the hypotensive response to intra-aortic injections of PGE2 in these hypertensive and normotensive rats. The depressor effect of PGE2 thus appears to have a significant reflex component mediated through cardiopulmonary receptors subserved by vagal afferents, with hypertensive rats exhibiting a lower threshold than normotensive rats. A vagally mediated reflex component to the depressor effect of PGE2 could not be demonstrated in normotensive rabbits or in rabbits and rats with chronic renovascular hypertension. Thus, a naturally occurring vasoactive substance can stimulate cardiopulmonary receptors subserved by vagal afferents in the rat, and spontaneously hypertensive rats appear to be especially sensitive to this effect. |
| Databáze: | OpenAIRE |
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