Enhanced Visuospatial Memory Following Intracerebroventricular Administration of Nerve Growth Factor
| Autor: | Françoise Schenk, Catherine Brandner, Guido Vantini |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Cognitive Neuroscience Central nervous system Hippocampus Experimental and Cognitive Psychology Escape response Spatial memory Choline O-Acetyltransferase Pharmacological treatment Behavioral Neuroscience Escape Reaction Orientation Nerve Growth Factor medicine Animals Humans Maze Learning Injections Intraventricular Dose-Response Relationship Drug Age Factors Brain Recombinant Proteins Frontal Lobe Rats medicine.anatomical_structure Nerve growth factor Frontal lobe Mental Recall Female Choline acetyltransferase activity Psychology Neuroscience |
| Zdroj: | Neurobiology of Learning and Memory. 73:49-67 |
| ISSN: | 1074-7427 |
| DOI: | 10.1006/nlme.1999.3917 |
| Popis: | The present work assessed the effects of intracerebroventricular injections of rh recombined human nerve growth factor (rh NGF) (5 micrograms/2.5 microl) at postnatal days 12 and 13 upon the development of spatial learning capacities. The treated rats were trained at the age of 22 days to escape onto an invisible platform at a fixed position in space in a Morris navigation task. For half of the subjects, the training position was also cued, a procedure aimed at facilitating escape and at reducing attention to the distant spatial cues. Later, at the age of 6 months, all the rats were trained in a radial-arm maze task. Treatment effects were found in both immature and adult rats. The injection of NGF improved the performance in the Morris navigation task in both training conditions. There was a significant reduction in the escape latency and an increased bias toward the training platform quadrant during probe trials. The most consistent effect was the precocious development of an adult-like spatial memory. In the radial-arm maze, the NGF-treated rats made significantly fewer reentries than vehicle rats and this effect was particularly marked in the treated female rats. Taken together, these experiments reveal that the development and the maintenance of an accurate spatial representation are tightly related to the development of brain structures facilitated by the action of NGF. Moreover, these experiments demonstrate that an acute pharmacological treatment that leads to a transient modification in the choline acetyltransferase activity can induce a behavioral change long after the treatment. |
| Databáze: | OpenAIRE |
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