Importância do metabolismo no planejamento de fármacos

Autor:	Dárcio Gomes Pereira
Jazyk:	portugalština
Rok vydání:	2007
Předmět:	Chemistry Drug discovery drug design structure-metabolism relationship General Chemistry Prodrug Pharmacology drug metabolism Pharmacokinetics Ezetimibe medicine Ritonavir Bambuterol Enalapril Active metabolite medicine.drug
Zdroj:	Química Nova, Volume: 30, Issue: 1, Pages: 171-177, Published: FEB 2007 Química Nova v.30 n.1 2007 Química Nova Sociedade Brasileira de Química (SBQ) instacron:SBQ
Popis:	It is widely recognized that pharmacokinetic optimization needs to be addressed early in drug discovery to reduce the high failure rate in bringing drugs to market. Poor absorption, too short duration of action due to high elimination rate, or the presence of active metabolites are examples of properties that can potentially lead to unsuccessful clinical programmes. Here I describe a brief overview of advantages and molecular strategies for improving metabolic and pharmacokinetic properties applied to the discovery of fluconazol, beta-blockers, ritonavir and ezetimibe and to the development of the prodrugs enalapril and bambuterol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ab43acdb5cebaea8903e3efa3e24ce http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000100029&lng=en&tlng=en Zobrazit plný text záznamu