Direct Decarboxylative-Decarbonylative Alkylation of α-Oxo Acids with Electrophilic Olefins via Visible-Light Photoredox Catalysis
| Autor: | Yun-Long Wei, Rui Chang, Peng-Fei Xu, Zhu-Yin Wang, Jia-Nan Mo, Jian-Qiang Chen |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Primary (chemistry) 010405 organic chemistry Radical Organic Chemistry Decarbonylation nutritional and metabolic diseases Photoredox catalysis Alkylation 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry Electrophile lipids (amino acids peptides and proteins) Alkyl Visible spectrum |
| Zdroj: | The Journal of organic chemistry. 83(1) |
| ISSN: | 1520-6904 |
| Popis: | The decarbonylation of primary, secondary, and tertiary alkyl-substituted acyl radicals has been investigated through photoredox catalysis. A series of quaternary carbons and γ-ketoesters have been directly constructed by the photoredox 1,4-conjugate addition of the corresponding alkyl ketoacids with electrophilic alkenes. And, the tertiary alkyl ketoacids have proved to be good precursors of tertiary alkyl radicals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|