Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms
| Autor: | José María Gutiérrez, Julián Fernández, Jay W. Fox, Bruno Lomonte, Alexandra Rucavado, Cristina Herrera, Teresa Escalante |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Snake venom Injury control Accident prevention Snake Bites Poison control Hemorrhage Viper Venoms Toxicology Myonecrosis complex mixtures Pathogenesis 03 medical and health sciences Tissue damage Viperidae Animals Edema Medicine Elapidae Skin Elapid Venoms Inflammation DAMPs business.industry Muscles Extracellular Matrix 030104 developmental biology Local tissue damage Blistering Identification (biology) 615.946 Venenos animales business Neuroscience |
| Zdroj: | Toxicon, vol. 148, pp. 123-131 Kérwá Universidad de Costa Rica instacron:UCR |
| ISSN: | 0041-0101 |
| DOI: | 10.1016/j.toxicon.2018.04.016 |
| Popis: | Snakebite envenoming by viperid species, and by some elapids, is characterized by a complex pattern of tissue damage at the anatomical site of venom injection. In severe cases, tissue destruction may be so extensive as to lead to permanent sequelae, with serious pathophysiological, social and psychological consequences. Significant advances have been performed in the study of venom-induced tissue damage, including identification and characterization of the toxins involved, insights into the mechanisms of action of venoms and toxins, and study of tissue responses to venom-induced injury. Nevertheless, much remains to be known and understood on the pathogenesis of these alterations. This review focuses on some of the pending issues in the topic of snake venom-induced local tissue damage. The traditional ‘reductionist’ approach, which has predominated in the study of snake venoms and their actions, needs to be complemented by more integrative and holistic perspectives aimed at capturing the complexity of these pathological alterations. Future advances in the study of these topics will certainly pave the way for innovative therapeutic interventions, with the goal of reducing the impact of this aspect of snakebite envenoming. UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP) UCR::Vicerrectoría de Docencia::Salud::Facultad de Microbiología UCR::Vicerrectoría de Docencia::Salud::Facultad de Farmacia |
| Databáze: | OpenAIRE |
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