Imaging of Prostate Specific Membrane Antigen Targeted Radiotracers for the Detection of Prostate Cancer Biochemical Recurrence after Definitive Therapy: A Systematic Review and Meta-Analysis
| Autor: | Matthew S. Davenport, Jeremie Calais, Udochukwu Oyoyo, Nelly Tan, I. Baris Turkbey, Esther Mena, Johnathan Kim, Niusha Bavadian |
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| Rok vydání: | 2019 |
| Předmět: |
Glutamate Carboxypeptidase II
Male Oncology Biochemical recurrence medicine.medical_specialty Urology Definitive Therapy 030232 urology & nephrology 03 medical and health sciences Prostate cancer 0302 clinical medicine Neoplasm Recurrence Positron Emission Tomography Computed Tomography Internal medicine medicine Medical imaging Glutamate carboxypeptidase II Humans Radioactive Tracers business.industry Prostatic Neoplasms medicine.disease Meta-analysis Antigens Surface Neoplasm Recurrence Local business |
| Zdroj: | Journal of Urology. 202:231-240 |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1097/ju.0000000000000198 |
| Popis: | Prostate specific membrane antigen targeted radiotracers are promising agents for imaging patients with prostate cancer biochemical recurrence after definitive therapy. We report the results of a systematic review and meta-analysis of the detection of biochemical recurrence after definitive therapy for prostate cancer stratified by prostate specific antigen levels and using prostate specific membrane antigen targeted radiotracers.According to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Diagnostic Test Accuracy guidelines, we searched for articles in PubMed® and EMBASE® databases in our systematic review from 2012 to July 2018. Studies evaluating men with prostate cancer biochemical recurrence after definitive therapy and without known metastatic disease who underwent prostate specific membrane antigen positron emission tomography/computerized tomography to detect recurrent disease were included in analysis. The risk of bias and applicability concerns were assessed by QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies 2). Statistical heterogeneity was assessed with the Cochrane Q and an IA total of 5,113 patients in 43 studies were included in this systematic review. Of the studies 15 (34.8%) were prospective, 3 (6.9%) were multi-institutional and the remainder were done at a single center. A total of 18 studies (41.8%) were done in subjects after radical prostatectomy, 2 (4.6%) were in subjects after radiotherapy and 23 (53.5%) were in subjects after radical prostatectomy and radiotherapy. Median prostate specific antigen was 1.6 ng/ml (IQR 0.7-4.4) and median subject age was 68 years (IQR 67-70). Of the 43 studies 33 (76.7%) evaluatedProstate specific membrane antigen targeted radiotracers are likely effective to detect biochemically recurrent prostate cancer at low prostate specific antigen levels. However, existing studies are limited by retrospective design, limited reference standards, publication bias and a lack of interagent comparison. |
| Databáze: | OpenAIRE |
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