Incorporating systems-level stakeholder perspectives into the clinical trial design of school-supervised asthma therapy
| Autor: | Wanda Phipatanakul, Lynn B. Gerald, Michelle Spano, Lori Pbert, Hallie Pearl, Janki Luther, Michelle Trivedi, Holly Shillan, Shushmita Hoque, Hannah L. Seay |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Schools business.industry Public health Clinical study design Stakeholder Stakeholder engagement General Medicine Article Asthma Health equity Clinical trial Nursing Research Design Health care medicine Humans Pharmacology (medical) Thematic analysis Child business Randomized Controlled Trials as Topic |
| Zdroj: | Contemp Clin Trials |
| ISSN: | 1551-7144 |
| Popis: | Rationale Few evidence-based public health interventions are adopted in practice, in part due to a disconnect between the outcomes measured in clinical trials and the outcomes important to stakeholders that determine implementation in real-world practice. AsthmaLink is a school-supervised asthma therapy program which partners pediatric providers, school nurses, and families. To inform the design of a cluster randomized controlled trial of AsthmaLink, we elicited systems-level stakeholder input. Methods Maximum variation sampling was used to recruit 18 stakeholders to participate in semi-structured interviews that were recorded, transcribed, and open coded: Department of Public Health officials (n = 4), school officials (n = 4), pediatric practice managers (n = 3), health insurance officials (n = 4), and legislators (n = 3). Thematic analysis was used to identify common themes related to stakeholder priorities for clinical trial design and perceived barriers to AsthmaLink adoption. Results Stakeholder groups identified common priorities for the clinical trial design, including examination of the extent to which AsthmaLink (1) reduces health care utilization, (2) is cost effective (2) addresses health disparities, (3) reduces school absenteeism, and (4) educates families about asthma. Stakeholder groups reported potential barriers to AsthmaLink adoption, including challenges pertaining to (1) securing resources, staffing, and reimbursement, (2) variability across school districts, and (3) standing out amidst multiple programs vying for resources. Conclusions Systems-level stakeholder input informed refinements to the clinical trial design of a school-supervised therapy program including outcome and implementation measures and choice of study population. Incorporating systems-level stakeholder perspectives into clinical trial design is critical to achieve adoption of evidence-based interventions into practice. |
| Databáze: | OpenAIRE |
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