Circadian Clock Control of Liver Metabolic Functions
| Autor: | Hans Reinke, Gad Asher |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Time Factors Circadian clock Endogeny Biology 03 medical and health sciences Non-alcoholic Fatty Liver Disease Internal medicine Detoxification medicine Animals Homeostasis Humans Circadian rhythm Hepatology Suprachiasmatic nucleus Circadian Rhythm Signaling Peptides and Proteins Fatty liver Gastroenterology Metabolism medicine.disease Circadian Rhythm 030104 developmental biology Endocrinology Liver Inactivation Metabolic Energy Metabolism Neuroscience Signal Transduction |
| Zdroj: | Gastroenterology. 150(3) |
| ISSN: | 1528-0012 |
| Popis: | The circadian clock is an endogenous biological timekeeping system that synchronizes physiology and behavior to day/night cycles. A wide variety of processes throughout the entire gastrointestinal tract and notably the liver appear to be under circadian control. These include various metabolic functions such as nutrient uptake, processing, and detoxification, which align organ function to cycle with nutrient supply and demand. Remarkably, genetic or environmental disruption of the circadian clock can cause metabolic diseases or exacerbate pathological states. In addition, modern lifestyles force more and more people worldwide into asynchrony between the external time and their circadian clock, resulting in a constant state of social jetlag. Recent evidence indicates that interactions between altered energy metabolism and disruptions in the circadian clock create a downward spiral that can lead to diabetes and other metabolic diseases. In this review, we provide an overview of rhythmic processes in the liver and highlight the functions of circadian clock genes under physiological and pathological conditions; we focus on their roles in regulation of hepatic glucose as well as lipid and bile acid metabolism and detoxification and their potential effects on the development of fatty liver and nonalcoholic steatohepatitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|