SARS-CoV-2 vaccine research and development: Conventional vaccines and biomimetic nanotechnology strategies
| Autor: | Fu-Bing Wang, Qian Zhang, Qin Pan, Lanxiang Huang, Kezhen Yi, Jianyuan Wu, Xuan Tang, Yuan Rong, Wei Wang |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Vaccine research
Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses Pharmaceutical Science Virus-like nanoparticles 02 engineering and technology Disease RM1-950 010402 general chemistry medicine.disease_cause 01 natural sciences Article Pandemic Medicine Biomimetic nanotechnology Coronavirus Pharmacology business.industry SARS-CoV-2 COVID-19 021001 nanoscience & nanotechnology medicine.disease Virology 0104 chemical sciences Middle East respiratory syndrome Personalized medicine Therapeutics. Pharmacology 0210 nano-technology business Vaccine |
| Zdroj: | Asian Journal of Pharmaceutical Sciences, Vol 16, Iss 2, Pp 136-146 (2021) Asian Journal of Pharmaceutical Sciences |
| ISSN: | 1818-0876 |
| Popis: | The development of a massively producible vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, is essential for stopping the current coronavirus disease (COVID-19) pandemic. A vaccine must stimulate effective antibody and T cell responses in vivo to induce long-term protection. Scientific researchers have been developing vaccine candidates for the severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) since the outbreaks of these diseases. The prevalence of new biotechnologies such as genetic engineering has shed light on the generation of vaccines against novel viruses. In this review, we present the status of the development of coronavirus vaccines, focusing particularly on the biomimetic nanoparticle technology platform, which is likely to have a major role in future developments of personalized medicine. Graphical Abstract Coronavirus vaccine development. COVID-19 is encoded by single-stranded RNA and consists of spike proteins, nucleocapsid proteins, envelope proteins, and membrane proteins. Among them, spike proteins are composed of S1 and S2 subunits, and the receptor binding domain is located on the S1 protein. Coronavirus vaccine development from conventional vaccine to biomimetic nanotechnology vaccine. Image, graphical abstract |
| Databáze: | OpenAIRE |
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