Correlation of HIF-1α/HIF-2α expression with FDG uptake in lung adenocarcinoma
| Autor: | Yuka Nakamura, Hisao Tonami, Motoyasu Sagawa, Toshiaki Yamagishi, Kotaro Higashi, Yoshimichi Ueda, Yasuhito Ishigaki, Manabu Oguchi, Miyako Shimasaki, Tsutomu Takegami |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Lung Neoplasms Adenocarcinoma of Lung Adenocarcinoma Disease-Free Survival Correlation 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 medicine Basic Helix-Loop-Helix Transcription Factors Humans Radiology Nuclear Medicine and imaging Aged Aged 80 and over Univariate analysis Glucose Transporter Type 1 Lung business.industry Fdg uptake Biological Transport General Medicine Hypoxia (medical) Middle Aged medicine.disease Hypoxia-Inducible Factor 1 alpha Subunit carbohydrates (lipids) 030104 developmental biology medicine.anatomical_structure Hypoxia-inducible factors 030220 oncology & carcinogenesis Immunohistochemistry Female medicine.symptom business |
| Zdroj: | Annals of nuclear medicine. 30(10) |
| ISSN: | 1864-6433 |
| Popis: | Hypoxia is a key element involved in the development and progression of tumors. HIF-1α may transiently induce and mediate the response to acute and severe hypoxia, while HIF-2α may induce a longer response and may control the response to chronic and moderate hypoxia. Hypoxia increases the cellular uptake of FDG. Therefore, HIF may play an important role in the process of the cellular uptake of FDG. The aim of this study was to compare HIF-1α/HIF-2α expression with FDG uptake, Glut-1 expression, and prognosis in the patients with lung adenocarcinoma and to investigate the role of HIF-1α/HIF-2α in the uptake of FDG in lung adenocarcinoma. In the current work, we compared the immunohistochemical expression of HIF-1α and HIF-2α in surgical specimens of 44 patients with lung adenocarcinoma. The relationships between HIF-α expression and Glut-1 expression, FDG uptake, and clinicopathological factors, including prognosis, were analyzed. There was a marginal association between HIF-1α and HIF-2α expressions (P = 0.076). We found a significant correlation between HIF-2α expression and FDG uptake (P = 0.0001). HIF-1α expression showed a marginal association with FDG uptake (P = 0.066). FDG uptake correlated more significantly with HIF-2α expression than with HIF-1α expression. A significant correlation was noticed between Glut-1 expression and both HIF-1α and HIF-2α expressions (P = 0.005 and P = 0.003, respectively). Univariate analysis of disease-free survival demonstrated that FDG uptake and HIF-2α expression, but not HIF-1α expression, were related to recurrence (P |
| Databáze: | OpenAIRE |
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