A model for investigating the effect of drugs on the peripheral sympathetic nervous system in man
| Autor: | John A. Walsh, Robert W. Basedow, Christopher J. Glynn, Margaret Marzola |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adult
Guanethidine Male Sympathetic nervous system Sympathetic Nervous System Adolescent Physiology Sympatholytic Drugs Sympatholytic medicine Humans Aged Tourniquet business.industry General Neuroscience Sympathetic activity Blood flow Middle Aged Hand Peripheral medicine.anatomical_structure Regional Blood Flow Vasoconstriction Anesthesia Female Neurology (clinical) Nervous System Diseases Skin Temperature business medicine.drug |
| Zdroj: | Journal of the Autonomic Nervous System. 5:195-205 |
| ISSN: | 0165-1838 |
| DOI: | 10.1016/0165-1838(82)90039-x |
| Popis: | A model for assessing the effect of sympatholytic drugs on the peripheral sympathetic nervous system in man is described. Guanethidine, a sympatholytic drug, and the vehicle have been used to explore the model which is based on the Bier block. Sympathetic activity was assessed by measuring: (i) palmar sweating; (ii) skin temperature; (iii) radial/brachial pressure index; (iv) hand blood flow; and (v) vasoconstrictor ice response of hand blood flow. Neither the tourniquet nor the vehicle had any effect on sympathetic activity whereas guanethidine produced significant changes in skin temperature (P less than 0.05), hand blood flow (P less than 0.001) and the vasoconstrictor ice response (P less than 0.002), illustrating the usefulness of the model. |
| Databáze: | OpenAIRE |
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