Trophic Actions of Oral Vanadium and Improved Glycemia on the Pancreatic Beta-Cell Ultrastructure of Streptozotocin-Induced Diabetic Rats
| Autor: | Mohammadi, M. T., Leila Pirmoradi, Mesbah, F., Safaee, A., Dehghani, G. A. |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Scopus-Elsevier |
| DOI: | 10.6092/1590-8577/2855 |
| Popis: | Context Oral vanadyl sulfate (vanadium) has potent hypoglycemic effects in diabetes animals, but data about its actions on pancreatic beta-cells (BC) ultrastructure is limited. Objective Partial diabetic rats were treated with vanadium and insulin injection and their effects on BC ultrastructure are studied. Methods Male rats were made diabetic with intravenous streptozotocin injection (STZ, 40 mg/kg). Animals were randomly divided to control (CD), vanadium-treated (1 mg/mL VOSO4 + 5H2O in base solution, VTD) and insulin-treated (80 U/kg/day NPH insulin injection, ITD) diabetic groups. Treatments started 10 days after STZ injection and terminated after 2 months. Intermittent tail blood samples were taken for measurements of blood glucose (BG) and plasma insulin (PI). Finally animals were sacrificed and pancreata prepared for assessments of BC ultrastructure, islets histology and insulin immunoreactivity (IIR). Results Vanadium decreased BG (P JOP. Journal of the Pancreas, Vol 15, No 6 (2014): November - p. 541-632 |
| Databáze: | OpenAIRE |
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